Study sets, textbooks, questions
Upgrade to remove ads
Terms in this set (30)
First immunoglobulin to appear in the bloodstream after the first exposure to an antigen (primary antibody response)
Secretory antibody response
Major antibody to protein antigens
Clinically similar to anaphylaxis
Not IgE mediated
Does not require previous exposure
When does a child begin developing antibodies?
Between 6 and 12 months
IgE mediated hypersensitivity response
History of exposure, Rapid onset of symptoms, Serum Tryptase (1,4 and 8 hours)
Risk factors for severe anaphylactic reaction
Tx of anaphylaxis
-Airway, breathing, circulation (ABC)
-Epinephrine (1:1,000-0.01 mL/kg subcutaneously). Minimum dose:0.1
mL. Maximum dose: 0.3. mL
-Diphenhydramine 1 to 2mg/kg IV, IM, or PO q4-6h
-Cimetidine 5 to 10mg/kg IV q6h (refractory cases)
Name the different types of hypersensitivity immune responses
Type 1: Anaphylactic or immediate hypersensitivity rxn - IgE mediated (anaphylaxis, allergic rhinitis, allergic asthma, acute urticaria)
Type 2: Cytotoxic antibody mediated - IgM, IgG antibodies against antigens bound to cell membrane structures (immune hemolytic anemia, Rh hemolytic disease in the newborn, graves disease etc)
Type 3: Immune complex mediated - complexes of circulating antigens and IgM or IgG (serum sickness, PSGN)
Type 4: Delayed hypersensitivity/cell mediated - T lymphocytes - mantoux, contact dermatitis
Defin: Acute disseminated form of Langerhans' cell histiocytosis. Manifestation of complex immune dysregulation.
Def'n: Telangiectasia, ataxia, variable immunodeficiency, autosomal recessive
Etiology: Defective chromosome repair
S+S: Progressive cerebellar ataxia - usually presents during first 6 years, in wheelchair by 10-12.
What is the earliest site of telangiectasia in ataxia-telangiectasia?
Chronic mucocutaneous candidiasis
Def'n: T-Cell disorder.
Superficial candidal infections of mucous membranes, skin and nails. Often associated with endocrinopathy.
Common variable hypogammaglobulinemia (CVID)
Def'n: Inherited disorder of hypogammaglobulinemia, infections less severe than SCID, Involves the formation of autoantibodies.
Bruton's Congenital Agammaglobulinemia
Def'n: Profound defects in B lymphocytes (both function and number). Severe hypogammaglobulinemia, X-linked.
Increased susceptibilty to infxns with strep, H. Flu, Echovirus meningoencephalitis
Hypoplasia of tonsils, adenoids and peripheral LNs
When do infant's with Bruton's congenital agammaglobulinemia present?
Infant's with bruton's congenital agamaglobulinemia remain well for the first 6-9 months because of maternal transmitted IgG antibodies.
Most common immunoglobulin deficiency
Selective IgA deficiency. Avoid X-ray exposure.
When should a patient with Selective IgA deficiency get blood products or IVIG?
Selective IgA deficiency can lead to fatal anaphylactic reaction to blood products and IVIG. Immunoglobulin therapy is contraindicated.
What is selective IgA deficiency?
Deficiency of IgA predominant immunoglobulin on mucosal surfaces.
- Most common humoral antibody deficiency.
Signs and Symptoms:
Respiratory tract infections
Urinary tract infections
Gastrointestinal Infections - Giardia
What is the major immunoglobulin within the upper airway
Definition: Primary disorder of T-cell function
Chromosome 22, q11 deletion
Abnormal development of third and fourth branchial pouches
Absent T lymphocytes - thymic hypoplasia
Signs and symptoms of DiGeorge's Sx
Congenital Heart Disease (ASD, VSD)
Right-Sided aortic arch
Abnormal Facies (Short philtrum, hypertelorism, low set ears)
Recognized functions of T-Lymphocytes
Cytotoxicity against virus-infected cells, mediation of delayed-type hypersensitivity, production of interleukin-2, and production of lymphokines
Tx of DiGeorge's Sx
Thymic tissue transplant
Bone marrow transplant - at risk for graft versus host disease
Use irradiated blood products only
Abnormal neutrophil function
Signs and Symptoms:
Increased susceptibility to infection of skin and respiratory tract
Mild bleeding diathesis
Partial oculocutaneous albinism
Progressive peripheral neuropathy
Dx: Large inclusions in all nucleated cells
Tx: High dose ascorbic acid, antibiotics for acute infections, bone marrow transplant (does not prevent or cure peripheral neuropathy)
Chronic Granulomatous Disease
Chemotaxis and phagocytosis intact
Most common inherited disorder of phagocytosis
Defect in generation of microbial oxygen metabolites
Inability to kill catalase-positive microorganisms
Signs and symptoms:
Severe recurrent infections of skin and lymph nodes
-congenital heart disease
Diagnosis of Chronic Granulomatous Disease
Impaired intracellular bactericidal activity is the definitive test for chronic granulomatous disease
Functions of Complement
Complement is a complex system of nine serum proteins (C1-C9)
Mediation of inflammation
Modulation of immune response
Requirements for graft vs host disease
Graft must contain immunocompetent cells
Host must be immunocompromised
Histocompatibility differences must exist
Sets with similar terms
SBS II IMMUNE SYSTEM DISEASES
LSU CLS Immunology Disorder Review
The principles of wellness and pathology
Chapter 16: Disorders in Immunity
Other sets by this creator
Other Quizlet sets
Antidepressants and Mood Stabilizers
Psych 140 Infant Learning