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What are the three classes of antiplatelet and thrombolytic drugs?

1. Antiplatelet drugs:
- ADP antagonist - Clopidogrel, Prasugrel
- TxA2 inhibitor - Aspirin
* Glycoprotein IIb/IIIa antagonist - abciximab

2. Drugs that decrease clot formation
- Anticoagulants - Heparin and Warfarin
* Thrombin antagonist - Hirudin

3. Drugs that dissolve clot
- t-PA
* Streptokinase

What are the steps involving hemostatic plug formation?

What are some factors in clotting that are current drug targets?

Explain hoe the antiplatelet drug Aspirin works.

What is the most common symptom of aspirin use?

What is the mechanism of action of Clopidogrel (Plavix)?

Describe the pharmacokinetics of Clopidogrel and an important drug interaction.

Describe the mechanism of action of Prasugrel, and how it is activated.

Describe the risks of bleeding in relation to using combined antiplatelet and thrombolytic drugs.

See GPIIb/IIIa mechanism of action on the back.

Explain the process of clot formation

Explain how thrombin leads to fibrinolysis.

What is the function of protein c?

What is the mechanism of action of heparin?

Se behind for additional information of heparin anticoagulative effects.

What are additional side effects of Heparin?

Explain Heparin Induced Thrombocytopenia (HIT)

What are some benefits and shortcomings of low molecular weight heparins (LMWHs)?

Explain the mechanism of action of Hirudin, advantages, indication, and limitations.

What is the mechanism of action of Warfarin. What are some side effects, and what natural anticoagulants are inhibited?

How are Heparin and Warfarin monitored?

As a clot forms, it also begins to be degraded. Amount of degradation is correlated to number of D-Dimers present. See behind.

Explain the mechanism of action of t-PA, and some potential side effects.

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