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5 Written questions

5 Matching questions

  1. pharmacokinetics of ketolides
  2. common examples of Fluoroquinolones
  3. photosensitivity
  4. pharmacodynamics of macrocodes
  5. aminoglycosides
  1. a -inhibits bacterial protein synthesis
    -gram - bact
    -reserved for serious infections
    -not absorbedvia GI tract; does not cross BBB
    -IM/IV only
    -gentamycin, tobramycin, amikacin, streptomycin
    -s/e: ototoxicity, nephrotoxicity, superinfection
    -peak levels drawn to monitor toxicity
    -troug levels to monitor maintenance of therapeutic drug levee
  2. b -cipro
    -levaquin
    -avelox
  3. c -orally: absorption by GI tract
    -not affected by food intake
    -excreted through feces, urine
    -t-1/2: 10 hrs
  4. d -increase risk with declomycin and long acting forms.
    -get sun-burnt 10x worse than average
  5. e -bacteriostatic
    -oral prepL onset of action 1 h, peak conc is 4 hrs and duration is 6hrs

5 Multiple choice questions

  1. -erthromycin (iv)
    -clarithromycin
    -azithromycin (long 1/2 life) (iv)
    -dirithromycin
  2. -gi n/v/d/ abdominal cramping
    -allergic rn are rare
    -when combined with other hepatotoxic drugs leads to hepatotoxicity; usually reversible when the drug is discnt.
  3. may increase serum levels of:
    -theophyline
    -carbamazepine
    -warfarin
    -do not administer with antacids bc may increase peak levels of macrolide
  4. -gi disturbances, photosensitivity, teratogenic effects (1st and 3rd), nephrotoxicity, superinfection, oral contraception may be decreased
  5. -bacteriostatic; with high doses can be bactericidal
    -used as pen sub.; diff in structure of pen
    -broad spectrum
    -used to treat mild-moderate infection of reps tract, sinuses, gi tract, skin, soft tissue, impetigo and STI
    -PO, slow IV
    -e-mycin drug of choice for Legionnaires mycoplasmal pneumonia

5 True/False questions

  1. extended macrolides-all inhibit protein synthesis
    -clarithromycin: 2x a day (BID)
    -azitromycin: QD x 5 days; t-1/2= 50 hours

          

  2. short acting tetracyclines-PO and IV
    -Vibramycin
    -minocin

          

  3. pharmacodynamics of glycopeptides-oral: treats antibiotic associated pseudomembranous colitis due to c.diff
    -IV: treats severe infections due to MRSA; septicemia; bone, skin, lower reps tract infect that are resistant to other antibiotics
    -t-1/2 life: 6 hrs
    -excretion via urine

          

  4. side effects of glycopeptide-vanocomycin
    -s/e: nephrotoxicity, ototoxicity damage (8th cranial nerve) can be permanent or temp, chills, dizziness, fever, rash, n/v

          

  5. intermediate acting Tetracyclines-PO only
    -Sumycin