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5 Written questions

5 Matching questions

  1. levaquin
  2. side effects/adverse run of macrolide
  3. macrolide drug interactions
  4. cipro
  5. pharmcokinetics of Fluoroquinolones
  1. a -gi n/v/d/ abdominal cramping
    -allergic rn are rare
    -when combined with other hepatotoxic drugs leads to hepatotoxicity; usually reversible when the drug is discnt.
  2. b -primarly treats URIs, acute sinusitis, chronic bronchitis, UTIs.
    -may cause dysrhythmias
  3. c may increase serum levels of:
    -do not administer with antacids bc may increase peak levels of macrolide
  4. d -broad spectrum of action; lower respitory infections, UTIs, bone, skin
  5. e -well absorbed from GI tract
    -low protein binding effect
    -moderate half life: 6-8 hrs
    -excreted via urine

5 Multiple choice questions

  1. -erthromycin (iv)
    -azithromycin (long 1/2 life) (iv)
  2. -increase risk with declomycin and long acting forms.
    -get sun-burnt 10x worse than average
  3. -gi disturbances, photosensitivity, teratogenic effects (1st and 3rd), nephrotoxicity, superinfection, oral contraception may be decreased
  4. -sub cat of macrolide
    -clindamycin: activate against most gram + and anaerobic org., absorbed better than lincocin vis gi tract, maintains a higher serum drug conc and fewer toxic effects
    -s/e: gi upset, rash
    -adverse rxn: colitis, anaphylactic shock
    -drug interactions: aminophyline, dilantin, barbiturates, ampicillin
  5. -vanocomycin
    -s/e: nephrotoxicity, ototoxicity damage (8th cranial nerve) can be permanent or temp, chills, dizziness, fever, rash, n/v

5 True/False questions

  1. other pcn sub., along w macrocodes-lincosamides


  2. Fluoroquinolones-bacteriostatic
    -used in combination to treat h.pylori
    -resistance has increased in treatment of pneumococcal and gonococcal infections
    -orally use mainly
    -available in IV/IM- rare cause of pain
    -not to be taken with magnesium/aluminum antacid preparations, calcium containing products.- prevents absorption


  3. pharmacodynamics of macrocodes-bacteriostatic
    -oral prepL onset of action 1 h, peak conc is 4 hrs and duration is 6hrs


  4. pharmacodynamics of aminoglycosides-IM/IV
    -shot half life; given 3-4 days daily
    -excreted via urine


  5. red neck (man) syndrome-all inhibit protein synthesis
    -clarithromycin: 2x a day (BID)
    -azitromycin: QD x 5 days; t-1/2= 50 hours


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