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5 Written questions

5 Matching questions

  1. ketolides
  2. pharmcokinetics of Fluoroquinolones
  3. macrolides
  4. levaquin
  5. pharmacodynamics of aminoglycosides
  1. a -bactericidal
    -preg cat. C
    -onset of action: immediate
    -peak action: 1-2 hrs
  2. b -bacteriostatic; with high doses can be bactericidal
    -used as pen sub.; diff in structure of pen
    -broad spectrum
    -used to treat mild-moderate infection of reps tract, sinuses, gi tract, skin, soft tissue, impetigo and STI
    -PO, slow IV
    -e-mycin drug of choice for Legionnaires mycoplasmal pneumonia
  3. c -well absorbed from GI tract
    -low protein binding effect
    -moderate half life: 6-8 hrs
    -excreted via urine
  4. d -primarly treats URIs, acute sinusitis, chronic bronchitis, UTIs.
    -may cause dysrhythmias
  5. e -structurally related to macrocodes
    -ketek: (18+) treats mild to moderate CAP
    -adverse rxn: may lead to an exacerbation of myashenia gravis
    -many drug interactions

5 Multiple choice questions

  1. -all inhibit protein synthesis
    -clarithromycin: 2x a day (BID)
    -azitromycin: QD x 5 days; t-1/2= 50 hours
  2. may increase serum levels of:
    -theophyline
    -carbamazepine
    -warfarin
    -do not administer with antacids bc may increase peak levels of macrolide
  3. -vanocomycin
    -s/e: nephrotoxicity, ototoxicity damage (8th cranial nerve) can be permanent or temp, chills, dizziness, fever, rash, n/v
  4. -readily absorbed from the GI tract; excretion in bile, feces, urine
    -only a small amy is excreted in urine, therefore renal insufficiency is not a contraindication for macrolide use
  5. -bacteriostatic
    -oral prepL onset of action 1 h, peak conc is 4 hrs and duration is 6hrs

5 True/False questions

  1. common examples of Fluoroquinolones-inhibits bacterial DNA synthesis by inhibiting the enzyme DNA gyrase
    -effect of oral hypoglycemics, theophylline and caffeine are increased with concurrent use of a Fluoroquinolones
    -peak con: 1-2 hrs

          

  2. Tetracyclines-bacteriostatic
    -used in combination to treat h.pylori
    -resistance has increased in treatment of pneumococcal and gonococcal infections
    -orally use mainly
    -available in IV/IM- rare cause of pain
    -not to be taken with magnesium/aluminum antacid preparations, calcium containing products.- prevents absorption

          

  3. pharmacodynamics of Fluoroquinolones-well absorbed from GI tract
    -low protein binding effect
    -moderate half life: 6-8 hrs
    -excreted via urine

          

  4. cipro-broad spectrum of action; lower respitory infections, UTIs, bone, skin

          

  5. aminoglycosides-sub cat of macrolide
    -bacteriostatic/cidal
    -clindamycin: activate against most gram + and anaerobic org., absorbed better than lincocin vis gi tract, maintains a higher serum drug conc and fewer toxic effects
    -lincomycin
    -s/e: gi upset, rash
    -adverse rxn: colitis, anaphylactic shock
    -drug interactions: aminophyline, dilantin, barbiturates, ampicillin

          

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