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5 Written questions

5 Matching questions

  1. pharmacokinetics of aminoglycosides
  2. pharmacodynaamics of ketolides
  3. cipro
  4. aminoglycosides
  5. photosensitivity
  1. a -IM/IV
    -shot half life; given 3-4 days daily
    -excreted via urine
  2. b -inhibits bacterial protein synthesis
    -gram - bact
    -reserved for serious infections
    -not absorbedvia GI tract; does not cross BBB
    -IM/IV only
    -gentamycin, tobramycin, amikacin, streptomycin
    -s/e: ototoxicity, nephrotoxicity, superinfection
    -peak levels drawn to monitor toxicity
    -troug levels to monitor maintenance of therapeutic drug levee
  3. c -increase risk with declomycin and long acting forms.
    -get sun-burnt 10x worse than average
  4. d -inhibits protein synethsis in m.o by binding to ribosomal RNA which leads to bacterial cell death
    -peak action 1 hr
  5. e -broad spectrum of action; lower respitory infections, UTIs, bone, skin

5 Multiple choice questions

  1. -orally: absorption by GI tract
    -not affected by food intake
    -excreted through feces, urine
    -t-1/2: 10 hrs
  2. -PO only
    -declomycin
  3. -all inhibit protein synthesis
    -clarithromycin: 2x a day (BID)
    -azitromycin: QD x 5 days; t-1/2= 50 hours
  4. -primarly treats URIs, acute sinusitis, chronic bronchitis, UTIs.
    -may cause dysrhythmias
  5. -bacteriostatic
    -oral prepL onset of action 1 h, peak conc is 4 hrs and duration is 6hrs

5 True/False questions

  1. common examples of Fluoroquinolones-inhibits bacterial DNA synthesis by inhibiting the enzyme DNA gyrase
    -effect of oral hypoglycemics, theophylline and caffeine are increased with concurrent use of a Fluoroquinolones
    -peak con: 1-2 hrs

          

  2. pharmacodynamics of aminoglycosides-IM/IV
    -shot half life; given 3-4 days daily
    -excreted via urine

          

  3. avelox-more active against s. pneumoniae than levaquin is

          

  4. side effects/adverse run of macrolide-vanocomycin
    -s/e: nephrotoxicity, ototoxicity damage (8th cranial nerve) can be permanent or temp, chills, dizziness, fever, rash, n/v

          

  5. macrolide drug interactionsmay increase serum levels of:
    -theophyline
    -carbamazepine
    -warfarin
    -do not administer with antacids bc may increase peak levels of macrolide