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5 Written questions

5 Matching questions

  1. Fluoroquinolones
  2. side effects/adverse run of macrolide
  3. macrolide drug interactions
  4. pharmacokinetics of macrolides
  5. pharmacodynamics of glycopeptides
  1. a may increase serum levels of:
    -theophyline
    -carbamazepine
    -warfarin
    -do not administer with antacids bc may increase peak levels of macrolide
  2. b -readily absorbed from the GI tract; excretion in bile, feces, urine
    -only a small amy is excreted in urine, therefore renal insufficiency is not a contraindication for macrolide use
  3. c inhibits cell wall synthesis; active against several gr + bacteria; peaks 30min after IV infusion
  4. d -gi n/v/d/ abdominal cramping
    -allergic rn are rare
    -when combined with other hepatotoxic drugs leads to hepatotoxicity; usually reversible when the drug is discnt.
  5. e -interferes with enzyme DNA gyrase- needed to synthesize bacterial DNA
    -bactericidal on gram + and -
    -mainly used for tx of UTI, bone, joint infect; bronchitis, pneumonia, gastroenteritis, gonorrhea
    -high tissue distribution
    -food/antacids slow absorption rate

5 Multiple choice questions

  1. -erthromycin (iv)
    -clarithromycin
    -azithromycin (long 1/2 life) (iv)
    -dirithromycin
  2. -primarly treats URIs, acute sinusitis, chronic bronchitis, UTIs.
    -may cause dysrhythmias
  3. -lincosamides
    -gylcopeptides
    -ketolides
  4. -all inhibit protein synthesis
    -clarithromycin: 2x a day (BID)
    -azitromycin: QD x 5 days; t-1/2= 50 hours
  5. -bacteriostatic
    -oral prepL onset of action 1 h, peak conc is 4 hrs and duration is 6hrs

5 True/False questions

  1. cipro-broad spectrum of action; lower respitory infections, UTIs, bone, skin

          

  2. common examples of Fluoroquinolones-inhibits bacterial DNA synthesis by inhibiting the enzyme DNA gyrase
    -effect of oral hypoglycemics, theophylline and caffeine are increased with concurrent use of a Fluoroquinolones
    -peak con: 1-2 hrs

          

  3. red neck (man) syndrome-all inhibit protein synthesis
    -clarithromycin: 2x a day (BID)
    -azitromycin: QD x 5 days; t-1/2= 50 hours

          

  4. side effects and adverse effects to tetracyclines-gi n/v/d/ abdominal cramping
    -allergic rn are rare
    -when combined with other hepatotoxic drugs leads to hepatotoxicity; usually reversible when the drug is discnt.

          

  5. intermediate acting Tetracyclines-PO only
    -declomycin