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GABA facilitates the influx of ________ ____, depressing the excitiability of the post-synaptic neuron.
What are the overall sites of action?
limbic system centers (old brain, emotion), cerebral cortex and brainstem
Fear, anxiety and panic are mediated by what areas of the brain?
amygdala; orbitofrontal cortex; and insula
What are long-acting agents?
Benzos that are converted by the liver in active metabolites that must be converted again into inactive compounds before they can be excreted.
What area of the brain do low doses moderate anxiety, agitations and fear at ?
amygdala, orbitocortex, insula
What are common side effects?
sedation, drowsiness, ataxia, lethargy, mental confustion, motor impairment, cognitive impairment, disorientation, slurred speech, amnesia, hypnosis
What are normal withdrawal symptoms?
anxiety, insomnia, restlessness, agitation, irritability, unpleasant dreams
Three(3) Nonbenzodiazepine's BRZAs
Zolpidem(Ambien), Zaleplon(Sonata), Eszopiclone(Lunesta), all very short acting and GABA subtypes
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