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11. Inflammatory Bowel Disease
Terms in this set (26)
Name some examples of types of IBD besides Crohn's disease and ulcerative colitis.
- Ischemic Bowel
- Intermediate colitis
- Infective colitis
- Behcet's syndrome
- Lymphocytic colitis
- Collagenous colitis
Which immunoglobulin levels increase in response to IBD?
IgA, IgG and IgM
Which cytokines/interleukins are released in response to IBD?
IL-8, IL1B, TNF-α and TL1A
What does NOD stand for?
Nucleotide oligimerisation domain
What does PAMPs stand for?
Pathogen-associated molecular patterns
What is the function of NOD?
Detect the dysregulation of gut microbiota
What are the genetic factors that are associated with the development of Crohn's disease?
- DR5 DQ1 alleleS
- CARD15/NOD2 gene
- XBP1 gene
What are the genetic factors that are associated with the development of Ulcerative Colitis?
- DR2 alleles
- OCTN1 gene
- OCTN2 gene
Crohn's disease development is associated with the development of which T helper cell?
T helper 1 cell
Ulcerative colitis development is associated with the development of which T helper cell?
T helper 2 cell
Which areas of the intestines does Crohn's disease primarily affect?
Terminal ileum, stricture and sigmoid colon
Which areas of the intestines does ulcerative colitis primarily affect?
Descending colon and rectum
Which histological layers does Crohn's disease affect?
Mucosa, submucosa, muscularis propria and serosa
Which histological layers does ulcerative colitis affect?
Mucosa and submucosa
"Smoking reduces the risk of __ but increases the risk of developing __." (CD/UC or UC/CD)
Name an/some example(s) of (a) microbe(s) that is associated with the development of Crohn's disease.
Mycobacterium avium subspecies paratuberculosis and Enteroadherent Escherichia coli
Name an/some example(s) of (a) microbe(s) that is associated with the development of ulcerative colitis.
Outline a list of general symptoms of IBD conditions.
- abdominal pain
- rectal pain
- fistulae development
- perforation development
- abscess development
Does Crohn's disease affect young/old people?
Does ulcerative colitis affect young/old people?
What food types are responsible for the onset of IBD?
- Omega 6 fats
- Animal protein
Outline some examples of treatment for IBD.
- Faecal microbiota transplant
- Diet change
What is tenesmus?
The need to go poop poop but not the ability to follow through
What is a fistulae?
An connection between hollow spaces such as the intestines which does not normally occur
What is a perforation?
A hole in the stomach lining which allows stomach contents to escape into the abdominal space
What is uveitis?
The inflammation of the uvea in the eye
THIS SET IS OFTEN IN FOLDERS WITH...
1. Commensal Flora
2. Oral Microbiology
3. Healthcare Associated Infections (HCAIs)
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