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Pcol 2 Exam 4: 1-50

Terms in this set (50)

Acts as a sodium channel activator/agonist
A) Lindane
B) Malathion
C) Permethrin
D) Ivermectin
E) Spinosad
C
Agonistic at GABA and Cl-gated glutamate receptors
A) Lindane
B) Malathion
C) Permethrin
D) Ivermectin
E) Spinosad
D
Antagonistic at GABA receptors
A) Lindane
B) Malathion
C) Permethrin
D) Ivermectin
E) Spinosad
A
Irreversibly inhibits acetylcholinesterase
A) Lindane
B) Malathion
C) Permethrin
D) Ivermectin
E) Spinosad
B
Agonistic at the niconyl receptor
A) Lindane
B) Malathion
C) Permethrin
D) Ivermectin
E) Spinosad
E
Pharmacodynamically, ________ asphyxiates the louse by inhibiting respiratory spiracle activity.
A) Crotamiton
B) Spinosad
C) Malathion
D) Benzyl Alcohol
E) Permethrin
D
Concerning anti-parasiticals,
A) pharmacodynamically, ivermectin causes CNS depression
B) spinosad and malathion cause cholinergic overload
C) Permethrin may cause a burning sensation followed by numbness
D) All of the above
E) None of the above
D
The anthelminthic ________ acts by ________ to cause _________.
A) praziquantel - increasing calcium influx - tetanic paralysis
B) pyrantel - GABA inhibition - flaccid paralysis
C) albendazole - inhibition of pancreatic B cells- helminth cellular starvation
D) All of the above
E) None of the above
A
Pharmacodynamically, Ivermectin causes _______ as its vermicidal action
A) tetanic paralysis
B) flaccid paralysis
C) Non-depolarizing neuromuscular blockade
D) Decreased cellular respiration
E) decreased cellular glucose uptake
B
In treating intestinal helminthes, a patient should be counseled to take albendazole
A) with meals
B) on an empty stomach
C) for at least 10 days
D) A & C
E) B & C
B
Pharmacodynamically, albendazole causes ______ as its vermicidal action
A) decreased insulin release
B) increased motor center activity
C) non-depolarizing neuromuscular blockade
D) decreased cellular respiration
E) decreased cellular glucose uptake
E
The anti-malarial drug ______ is most likely to cause arrhythmias and episodes of psychoses as ADRs
A) Mefloquine
B) Primaquine
C) Artemether
D) Lumefantrine
E) Quinine
E
________ is the only anti-malarial that will successfully treat the tissue schizont and dormant forms of malaria.
A) Mefloquine
B) Primaquine
C) Artemether
D) Lumefantrine
E) Quinine
B
__________ exerts its effect via an endoperoxide based free radical.
A) Mefloquine
B) Primaquine
C) Artemether
D) Lumefantrine
E) Quinine
C
_______ disrupts haemozoin formation thus damaging the plasmoidal cell in treating malaria
A) Mefloquine
B) Primaquine
C) Artemether
D) Lumefantrine
E) Quinine
D
The anti-protozoal ________ will cause severe neurotoxicity if used at higher than recommended doses or for periods longer than three (3) weeks
A) Pentamidine
B) Iodoquinol
C) Miltefosine
D) Eflornithine
E) Atovaquone
B
_________ may cause severe hypotension and potentially irreversible diabetes mellitus as severe ADRs
A) Pentamidine
B) Iodoquinol
C) Miltefosine
D) Eflornithine
E) Atovaquone
A
_______ is an AKT protein kinase inhibitor that is used specifically to treat leishmaniasis
A) Pentamidine
B) Iodoquinol
C) Miltefosine
D) Eflornithine
E) Atovaquone
C
Pharmacodynamically, ________ inhibits polyamine synthesis to exhibit cellular proliferation and promote hair loss
A) Pentamidine
B) Iodoquinol
C) Miltefosine
D) Eflornithine
E) Atovaquone
D
Quinine and quinine-derived drugs are possibly effective in treating malaria by
A) disrupting DNA function/protein synthesis
B) altering the pH of erythrocytes
C) direct free radical damage
D) all of the above
E) none of the above
D
Tinidazole exerts its anti-protozoal effect by
A) DNA intercalation
B) inhibition of protein synthesis
C) free radical damage via a reduced nitro group
D) inhibition of ornithine decarboxylase
E) inhibition of tubulin
C
Metronidazole may
A) cause a disulfiram-like reaction
B) potentially cause cancer
C) precipitate torsades des pointes
D) A & B
E) A & C
D
_________ exerts its anti-protozoal effect by inhibiting pyruvate-ferrodoxin:oxido redeductase dependent ATP synthesis
A) Nitazoxanide
B) NIfurtimox
C) Metronidazole
D) Artesunate
E) Melarsoprol
A
_________ is the treatment of choice for American Trypanosomiasis
A) Nitazoxanide
B) NIfurtimox
C) Metronidazole
D) Artesunate
E) Melarsoprol
B
Inhibits 14-A-demethylase
A) Amphotericin
B) Griseofulvin
C) Itraconazole
D) Terbinafine
E) Amidulafungin
C
Inhibits B-(1,3)-D-glucan synthesis
A) Amphotericin
B) Griseofulvin
C) Itraconazole
D) Terbinafine
E) Amidulafungin
E
Binds to ergosterol in the fungal cell wall
A) Amphotericin
B) Griseofulvin
C) Itraconazole
D) Terbinafine
E) Amidulafungin
A
Inhibits squalene 2, 3 epoxidase
A) Amphotericin
B) Griseofulvin
C) Itraconazole
D) Terbinafine
E) Amidulafungin
D
Binds to and inhibits tubulin polymerization
A) Amphotericin
B) Griseofulvin
C) Itraconazole
D) Terbinafine
E) Amidulafungin
B
Pharmacodynamically, inhibition of ________ will inhibit ergesterol synthesis
A) 14-A-demethylase
B) tubulin polymerization
C) squalene 2,3 epoxidase
D) A & B
E) A & C
E
Pharmacodynamically, _______ will weaken the fungal cell wall
A) Caspofungin
B) Fluconazole
C) terbinafine
D) all of the above
E) none of the above
D
Torsades de pointes and 3A4 inhibition-related drug interactions
A) Ketoconazole
B) Griseofulvin
C) Terbinafine
D) Ciclopirox
E) Amphotericin
A
GI upset and severe hepatotoxicity
A) Ketoconazole
B) Griseofulvin
C) Terbinafine
D) Ciclopirox
E) Amphotericin
C
Thrombophlebitis, hypokalaemia, fever, and nephrotoxicity
A) Ketoconazole
B) Griseofulvin
C) Terbinafine
D) Ciclopirox
E) Amphotericin
E
Concerning anti-fungal therapy,
A) haloprogin acts by inhibiting fungal amino acid uptake
B) Keratophilic griseofulvin is better in treating onychomycoses
C) Ciclopirox is the preferred drug for ophthalmic fungal infections
D) B & C
E) All of the above
B
Inhibits DNA-dependent RNA polymerase-associated protein synthesis
A) Isoniazid
B) Rifampin
C) Ethambutol
D) Pyrazinamide
E) Bedaquiline
B
Inhibits NAD/NADH-mediated biochemical reactions
A) Ketoconazole
B) Griseofulvin
C) Terbinafine
D) Ciclopirox
E) Amphotericin
D
Inhibits arabinogalactan synthesis
A) Ketoconazole
B) Griseofulvin
C) Terbinafine
D) Ciclopirox
E) Amphotericin
C
Inhibits ATP synthase-mediated ATP synthesis
A) Ketoconazole
B) Griseofulvin
C) Terbinafine
D) Ciclopirox
E) Amphotericin
E
Inhibits mycolic acid synthesis
A) Ketoconazole
B) Griseofulvin
C) Terbinafine
D) Ciclopirox
E) Amphotericin
A
Considering isoniazid,
A) co-administration of niacin will minimize its neurotoxicity
B) its neurotoxicity is more apparent in patients deficient in G6PDH
C) it can cause mono- or bi-nocular color blindness
D) all of the above
E) none of the above
B
Bedaquiline is prone to cause
A) discoloration of the urine
B) nephrotoxicity
C) Torsades de pointes
D) all of the above
E) none of the above
C
Combination therapy is usually used in treating tuberculosis to
A) achieve additive/synergistic effects
B) overcome resistance
C0 shorten duration of therapy
D) all of the above
E) none of the above
D
The anti-leprosy drug _____ exerts its effect by inhibiting folate synthesis and may also be used in the treatment of brown recluse spider bites
A) clofazimine
B) thalidomide
C) dapsone
D) all of the above
E) none of the above
C
The drug ______ is primarily used for its anti-inflammatory effects in the treatment of Hansen's disease
A) clofazimine
B) thalidomide
C) dapsone
D) all of the above
E) none of the above
B
Used in treating resistant leprosy, _____ exerts its effect by inhibiting nucleic acid function.
A) clofazimine
B) thalidomide
C) dapsone
D) all of the above
E) none of the above
A
Mechanistically, the anti-tuberculotic drug ________ exerts its effect by inhibiting alanine racemase
A) Isoniazid
B) cyclserine
C) ethambutol
D) all of the above
E) none of the above
B
Pharmacodynamically, the anti-tuberculotic drug ______ is effective by inhibiting cell wall synthesis
A) Isoniazid
B) cyclserine
C) ethambutol
D) all of the above
E) none of the above
D
Concerning bactericidal drugs,
A) in general they act by inhibiting cell wall structure/function
B) they are bacteriocidal at sub-therapeutic doses
C) mechanistically, they disrupt ribosomal function
D) A & B
E) all of the above
A
Mechanistically, penicillins exert their activity by binding to and inhibiting
A) the penicillin binding protein
B) proteoglycan alanase
C) enolpyruvyl transferase
D) dihydropteroate synthase
E) alanine racemase
A
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