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23 terms

+ve ss RNA enveloped viruses

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retroviruses
virus family, all integrate and mutate but dont cause acute disease, acc contain reverse transcriptase
retroviruses
virus family, replication→latency, persistence, chronic disease, eg tumours, immunosuppression, ICD
FeLV
most important immunosup disease in UK cats
FeLV
cats, viruses labile & cell assoc., transmission by close contact / leucocytes in blood/milk/semen, vaccines
FeLV
cats, viraemia notable in BM, thymus, salivary gland and repro tracts, 40% recover, 30% viraemice w/out Ab, 30% die/intermittent excretors
FeLV
cats, cause repro failure, immune disease, multicentered/thymic/alimentary lymphosarcomas
FeLV
cats, test for envelope protein, antigen or capsid protein by sandwich ELISA, immunochromatography gives no false +ves, virus isolation at Glasgow
Sheep Pulmonary Adenomatosis
sheep, mammalian type D virus causing alvolar lining cell proliferation, ++fluid (wheelbarrow test), slow growing tumours and death. cull infected.
Avian Leukosis Virus
birds, avian Type C, vert/horiz transfer, subgroup A&B in 10% layers → B cell leukosis, subgroup J in 40% broilers→myeloid tumours, death, vaccine
Bovine Leukosis Virus
→bovine LN tumours, notifiable, cleared in 1999 by MAFF
FIV
cats, lentivirus, receptor CD134, isolates of varying virulence, transmission via saliva, milk, grooming, biting, mating. 10% of wandering males, ELISA for Ab or "one-step", no vaccine, neuter,
CD134
FIV receptor found on monocyte-derived macrophages & activated T cells
FIV
cats, virulent isolates→progressive CD4 (on Th cells) decline, high circulating virus→remission w/ ++Ab response (can→immune exhaustion)→rapidly progresses→feline AIDS or chronic immunosuppression
Visna Maedi Virus
sheep, rep in lung macrophages→brain, lungs, udder, joints, 2-6yrs→ICD Type IV, wasting (demyelination) and dyspnoea
Lentivirus
gennus characterised by long incubation periods, new variants arising every few months, causing immunosuppresssion and immune complex diseases
Visna Maedi Virus
sheep, infected animals remain virus&Ab+ve, transmission in aerosol, milk, colostrum, confirm w/ AGDT/ELISA, cull sero+ve, accreditation if 2 clear tests
Caprine Arthritis/Encephalitis Virus
goats lentivirus
Caprine Arthritis/Encephalitis Virus
goats, →ICD, encephalitis in kids, insidious polyarthritis in adults, in 10% British herds, 4% animals, clinical disease rare
Caprine Arthritis/Encephalitis Virus
goats, transmitted by mixing milk, sharing colostrum, so pretreat colostrum 56C for 1hr then artificial milk, keep kids/+ve mother separate
Equine Infectious Anaemia
aka Swamp Fever
Equine Infectious Anaemia
horses, lentivirus, notifiable
Equine Infectious Anaemia
infected horses have lifelong latent infection in macrophages, →Typpe III ICD, non-neutralising Ab + compliment →RBC lysis, death
Equine Infectious Anaemia
horses, carriers for several yrs despite Ab, transmission by swamp flies, needles, semen, milk, test spleen for Ab (immunodiffusion) or antigen (IF), slaughter, notifiable