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Pharm 29

Prilosec (omeprazole):

- 1 st PPI approved for PUD
- RX and OTC avail
- may take 2hrs to reach therap level
- effects last 72 hrs
- used short term (4-8wks)
- most sympt free aft 2 weeks
- most effective drug for ZE Synd
- oral only

Long term use of PPI's have shown an:

- increased risk for gastric cancer
- therapy usually limited to 2mos

Prilosec (omeprazole) used with warafin may cause:

increase risk of bleeding

Prilosec (omeprazole) interacts w:

certain drugs in increase the blood levels of certain drugs

Zegerid is a combo drug containing:

- omeprazole and
- sodium bicarbonate (antacid)

Zollinger-Ellison syndrome is:

hypersecretion of gastric acid

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