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Terms in this set (24)
What are the two kinds of flu vaccines?
inactivated, and live-attenuated (FluMist)
What are adverse effects of flu vaccines?
soreness, runny nose, nasal congestion, sore throat; hypersensitivity (due to eggs); Guillian-Barre Syndrome
What is the MOA of Amantadine and Rimantadine?
Inhbit viral uncoating by inhibiting acidification of the virus-containing endosome (blocks M2 membrane matrix protein)
Amantadine and Rimantadine are (were) effective against which type of influenza?
Why are Rimantadine and Amantadine no longer recommended for prophylaxis or treatment of influenza?
Amantadine and rimantadine mimic which endogenous neurotransmitter?
What types of influenza are targeted by neuramidase inhibitors?
A and B
Zanamivir causes cough, nasal congestion, throat discomfort, and possible bronchospasm. Therefore it is bad for asthmatics and COPD patients. Why doesn't Oseltamivir have these effects?
It is oral, whereas Zana. is inhaled
Which drug is used for respiratory syncytial virus (RSV) in infants and children?
How does Ribavirin work?
Guanosine analog that shuts down viral mRNA synthesis
Interferons are natural glycoproteins that inhibit viral RNA translation and lead to mRNA degradation. Which drugs are they added to to treat Hep B and C?
Hep B -- INF alpha + Lamivudine
Hep C -- INF alpha + Ribavirin
What is the main drug used for herpes?
How does acyclovir work?
Guanosine analog without a cyclic sugar, so it is a chain terminator.
It inhibits thymidine kinase!!
Why is cytomegalovirus resistant to acyclovir? What drug is used instead for CMV?
It doesn't have thymidine kinase.
What is Foscarnet?
Topical, nephrotoxic antiviral -- DNA polymerase inhibitor
Works for CMV, HSV, and HZV
In HAART therapy for HIV, three drugs are used. What type of drug are they?
2 -- reverse transcriptase inhibitors
1 -- protease inhibitor
How does Enfuvirtide work?
Viral infusion inhibitor--> GP41 fusion protein inhibitor
How does Raltegravir work?
Integrase inhibitor -- inhibits integration of viral strand DNA into host DNA
How do nucleoside reverse transcriptase inhibitors work?
Analogs of natural ribosides, but all lack 3'-OH group so that nothing can be added to them. DNA chain elongation is terminated.
What is the main adverse effect of Didanosine, an NRTI?
Which HIV drug decreases transmission of HIV to the fetus of infected mothers?
What drug population should be avoided in people taking Zidovudine?
How do protease inhibitors work?
Inhibit post-translational processing of viral polyproteins (the single, long polypeptide chain is not cut into smaller, functional ones)
How do you identify a protease inhibitor on the exam?
Anything that ends in "navir"
THIS SET IS OFTEN IN FOLDERS WITH...
Cell Wall Inhibitors
Protein Synthesis Inhibitors
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