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Multiple Sclerosis & Parkinson's
Terms in this set (25)
Autoimmune disease characterized by inflammation, selective demyelination, and gliosis
In Multiple Sclerosis, what mistakenly "attacks" the bodies myelin and myelin producing cells of the CNS?
T Cells, B Cells, and macrophages
____________ slows nerve conduction and causes nerves to fatigue quickly.
What pathways are commonly effected with multiple sclerosis?
optic pathway, corticospinal tracts, dorsal columns of the spinal cord and cerebral peduncles
When individuals with multiple sclerosis experience a temporary worsening of their impairments and increased fatigue when subjected to heat this is known as?
A clinical diagnosis of MS is made when there are __________.
Two or more attacks lasting longer than 24 hours and separated by more than one month
Cerebral Spinal Fluid may reveal elevated levels of myelin proteins and IgG bands (Way to diagnose MS)
Magnetic Resonance Imaging (MRI)?
MRI's will reveal acute lesions and chronic plaque formations in the brain and spinal cord (Way to diagnose MS)
Pharmacological Management of Multiple Sclerosis short term use?
immunosuppressant drugs, methotrexate, and anti-inflammatory drugs, corticosteroids, reduce the duration of MS attacks
Pharmacological Management of Multiple Sclerosis long term use?
Immunomodulating drugs, interferon, reduce frequency of MS attacks
Progressive disorder of the central nervous system with both motor and nonmotor symptoms
___________ causes a slow degeneration of the dopamine producing neurons in the substantia nigra.
What are the 4 cardinal signs of Parkinson's Disease?
Rigidity, bradykinesia, tremor and postural instability
Form of hypertonia, occur in both the agonists and antagonists, not velocity dependent
Hypertonia that is uniform throughout joint ROM
Hypertonia that is intermittent and catches throughout the joint ROM (Due to the combination of rigidity with tremor)
Inability to spontaneously smile and exhibit facial expressions
Slowed movement with a decrease in movement amplitude
Inability to initiate movement
Poor balance results from an inability to activate corrective postural strategies in response to perturbations or self-initiated movements
Are extensor or flexor muscles usually more affected with Parkinson's Disease?
Insufficient hip, knee, and ankle flexion combined with insufficient heel strike; reduced stride length and decreased foot clearance; decreased trunk rotation and reduced or absent arm swing
Uncontrolled increase in gait velocity, shortening of stride length; individual attempts to avoid falling by taking rapid short steps to catch up with their anteriorly displaced COM
Rigidity of the swallowing muscles and postural deformities causes impaired swallowing ability
Rigidity of the speech muscles cause problems with speech articulation
THIS SET IS OFTEN IN FOLDERS WITH...
Myasthenia Gravis patho
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