Myelogenous cells infiltrate the gingiva, causing swelling and bleeding
Form of cutaneous AML involvement
How do you dx a chloroma?
Greenish color from myeloperoxidase Fluoresces red under UV light
What are the labs for AML?
↑ WBC ↓ platelets normocytic, normochromic anemia
BM: hypercellular marrow with >30% blasts karyotyping has prognostic and tx value
What is the treatment for AML?
induction chemo achieves remission in 80%; 105 die from infection/bleeding prior to remission
SCT or BMT after remission from an appropriate donor can improve survival (graft-vs-leukemia effect favors allogeneic transplantation)
In lieu of transplant, maintenance chemo can be curative for some
Here's a review for CML.
2-3% of all childhood leukemia Features the Philadelphia chromosome with subsequent BCR-ABL gene rearrangement Presents with splenomegaly, thrombocytosis, leukocytosis Chronic phase in children lasts 3-4 years, followed by blast crisis, chronic phase may last 10-15 years in adults Treatment with imatinib (gleevec) results in 70% major response Stem cell transplantation or bone marrow transplant results in 80% cure rate
Here's a review for CLL.
same thing as small cell leukemia hypo-IgG, autoantibodies present & made by normal B cells, indicating immune disregulation over time, tumor cells displace the healthy marrow elements, resulting in anemia, thrombocytopenia, and neutropenia