5 Written questions
5 Matching questions
- What are the properties of the presumptive branch point?
- What enzymes are involved in Glycogen degradation?
- What is Uridine Diphosphate?
- What is the overall reaction of UDP glucose formation?
- What is glycogenin?
- a Must be at least 4 residues away from other branches. Links are alpha 1,6 glycosidic bond
- b Glycogen phosphorylase, Transferase, alpha 1,6 glucosidase, phosphoglucomutase
- c Glycogenin is both an enzyme and its substrate consisting of two 37 kD subunits. Each subunit catalyzes addition of a glycosyl unit from UDP glucose to Tyr 194 of other subunit. Subsequently, 7 more glycosyl units are added so that 8 glycosyl units are attached to Tyr 194 for each subunit
- d Glucose-1-phosphate +UTP =>UDP-glucose + PPi
- e Uridine diphosphate is a nucleotide composed of uracil, ribose and pyrophosphate
5 Multiple choice questions
- When glucose residues are removed to the "limit dextran" which is the 4th glucose residue from the branch glucose
- Transferase transfers the 3 terminal glucose residues from outer branch to the center, main linear branch
- A glycosyl unit from UDP glucose is transferred to the hydroxyl group at the C4 of the terminal glucose residue forming a alpha 1,4 glycosidic bond. Requires a glycogen molecule that is a minimum of 4 residues to which a glycosyl will be added
- Glucose 6 phosphatase converts Glucose 6 phosphate into glucose for export out of the liver and transport to other tissues
- The 4th glucose residue from the branch glucose
5 True/False questions
What does alpha 1,6 glucosidase do? → Alpha 1,6 glucosiase hydrolyzes the alpha 1,6 glucosidic bond to release a free glucose molecule
What is the overall reaction of glycogen phosphorylase activity? → Glycogen (n residues) + Pi=> glucose-1-phosphate + Glycogen (n-1 residues)
What irreversible reaction drives the synthesis of UDP-glucose? → PPi+ H2O=> 2Pi
What is phosphoglucomutase? → Phosphoglucomutase is a phospho enzyme and converts Glucose 1 phosphate to glucose 6 phosphate for further metabolism
What is glycogen? → Glycogenin is both an enzyme and its substrate consisting of two 37 kD subunits. Each subunit catalyzes addition of a glycosyl unit from UDP glucose to Tyr 194 of other subunit. Subsequently, 7 more glycosyl units are added so that 8 glycosyl units are attached to Tyr 194 for each subunit