5 Written questions
5 Matching questions
- What is debranching?
- What is the overall reaction of glycogen phosphorylase activity?
- What converts Glucose 6 phosphate into glucose in liver?
- What is the overall reaction of UDP glucose formation?
- What enzymes are involved in Glycogen degradation?
- a Glycogen phosphorylase, Transferase, alpha 1,6 glucosidase, phosphoglucomutase
- b Glucose 6 phosphatase converts Glucose 6 phosphate into glucose for export out of the liver and transport to other tissues
- c Glycogen (n residues) + Pi=> glucose-1-phosphate + Glycogen (n-1 residues)
- d When glucose residues are removed to the "limit dextran" which is the 4th glucose residue from the branch glucose
- e Glucose-1-phosphate +UTP =>UDP-glucose + PPi
5 Multiple choice questions
- Increases the number of terminal glucose residues which are site of action for glycogen phosphorylase and synthase. Branching increases rate of glycogen synthesis and degradation
- Uridine diphosphate is a nucleotide composed of uracil, ribose and pyrophosphate
- Phosphoglucomutase is a phospho enzyme and converts Glucose 1 phosphate to glucose 6 phosphate for further metabolism
- PPi+ H2O=> 2Pi
- UDP-glucose is synthesized from Uridine triphosphate and glucose-1-phosphate via the enzyme UDP-glucose pyrophosphorylase
5 True/False questions
What is glycogenin? → A very large, branched polymer of glucose residues. Most of the glucose residues are linked by alpha 1,4 glycosidic bonds. branches about every 10th residue are linked by alpha 1,6 glycosidic bonds
What enzyme catalyzes the transfer of glucose from UDP-glucose to a growing chain? → Glycogen synthase catalyzes transfer of glucose from UDP-glucose to a growing chain
What are the properties of the presumptive branch point? → Must be at least 4 residues away from other branches. Links are alpha 1,6 glycosidic bond
What does transferase do? → When glucose residues are removed to the "limit dextran" which is the 4th glucose residue from the branch glucose
What are the properties of Glycogen synthase? → Utilizes a non branched string of at least 11 glycosyl residues long. Branching enzyme transfers a string of typically 7 residues from non reducing end to presumptive branch point.