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5 Written questions

5 Matching questions

  1. What is tolerance?
  2. What is Steven's Johnson Syndrome? What causes it?
  3. What nursing actions should be taken before administration of antiinfectives?
  4. Hydrochlorothiazide (HCTZ)
  5. Define nephrotoxicity. What labs is involved?
  1. a ask about any allergies to penicillin, drug history, take culture of infection, ask about any liver or kidney diseases
  2. b indications: HTN, edema, diabetes insipidus
    AE: hyponatremia, hypochloremia, hypokalemia, dehydration, hyperglycemia, hyperuricemia, increase LDL, increase excretion of mg
    - monitor i/o, weigh pt
    -do not take while pregnant or breast-feeding
    - interacts with digoxin, antihypertensive drugs, lithium, and NSAIDs
  3. c a decreasing response to repetitive drug doses
  4. d - widespread lesions of skin and mucous membranes
    - fever, malaise, toxemia, can be fatal
    - mostly happens with sulfonamides
  5. e - toxicity in the kidneys
    - BUN (11-23 mg/dL) and creatinine (0.6-1.2 mg/dL)
    - creatinine clearance in the elderly is the best, collect urine for 24 hrs

5 Multiple choice questions

  1. fast acting due to skipping the absorption period
    control of drug levels in blood
    use of large fluid volumes
    use of irritant drugs
    - can't reverse w/o antidote, expensive
  2. cause: clindamycin, amoxicillin, ampicillin, cephalexin
    bacterial infection - contact, hand sanitizer doesn't kill it!
    treatments: metronidiazole (Flagyl) or vanco
  3. indications: 1st drug to treat HIV
    AE: severe anemia and neutropenia, bone marrow suppression, liver damage, gi effects
  4. - to minimize the risk of injury, IV admin should be performed only into a vein w/ good flow.
    - Sites of previous irradiation should be avoided
    - If extravasation occurs, infusion d/c immediately
    - extreme caution should be employed
  5. indications: mainly HTN, edema, <3 failure, and commonly in combo with a thiazide or loop diuretic.
    -spironalactone counteracts the K-wasting effects of the more powerful diuretics
    AE: hyperkalemia, benign and malignant tumors, endocrine effects (gynecomastia, menstrual irregularities, impotence, hirutism (excessive hair growth in women) and deepening of the voice)

5 True/False questions

  1. Define antagonistproduce their effects by preventing receptor activation by endogenous regulatory molecules and drugs.
    Has affinity, but not intrinsic activity
    no receptor activation


  2. Pseudoephredine (Sudafed)indications: nasal decongestant, causes vasoconstriction of blood vessels in nose
    AE: CNS stimulation (restlessness, irritability, anxiety), use cautiously in pts w/ HTN and CAD


  3. Tetracyclinesindications:pain
    AE: respiratory depression, bradycardia, allergic reactions, constipation
    antidote: narcan, give colace for constipation


  4. NSAIDs (buprofen)an agent or factor that causes a malformation of an embryo.
    1- drug must cause a characteristic set of malformations
    2-must act only during a specific window of vulnerability (wks 4-7 of gestation)
    3-incidence of malformations should increase with increasing dosage and duration of exposure


  5. Propylthiouracil (PTU)indications: treats streptococcus pneumonia and pyrogenes
    AE: allergic reactions, pain at injection site, sensory/motor dysfunction, neurotoxicity if blood levels too high
    *alternative = erythromycin