5 Written questions
5 Matching questions
- What is tolerance?
- What is Steven's Johnson Syndrome? What causes it?
- What nursing actions should be taken before administration of antiinfectives?
- Hydrochlorothiazide (HCTZ)
- Define nephrotoxicity. What labs is involved?
- a ask about any allergies to penicillin, drug history, take culture of infection, ask about any liver or kidney diseases
- b indications: HTN, edema, diabetes insipidus
AE: hyponatremia, hypochloremia, hypokalemia, dehydration, hyperglycemia, hyperuricemia, increase LDL, increase excretion of mg
- monitor i/o, weigh pt
-do not take while pregnant or breast-feeding
- interacts with digoxin, antihypertensive drugs, lithium, and NSAIDs
- c a decreasing response to repetitive drug doses
- d - widespread lesions of skin and mucous membranes
- fever, malaise, toxemia, can be fatal
- mostly happens with sulfonamides
- e - toxicity in the kidneys
- BUN (11-23 mg/dL) and creatinine (0.6-1.2 mg/dL)
- creatinine clearance in the elderly is the best, collect urine for 24 hrs
5 Multiple choice questions
- fast acting due to skipping the absorption period
control of drug levels in blood
use of large fluid volumes
use of irritant drugs
- can't reverse w/o antidote, expensive
- cause: clindamycin, amoxicillin, ampicillin, cephalexin
bacterial infection - contact, hand sanitizer doesn't kill it!
treatments: metronidiazole (Flagyl) or vanco
- indications: 1st drug to treat HIV
AE: severe anemia and neutropenia, bone marrow suppression, liver damage, gi effects
- - to minimize the risk of injury, IV admin should be performed only into a vein w/ good flow.
- Sites of previous irradiation should be avoided
- If extravasation occurs, infusion d/c immediately
- extreme caution should be employed
- indications: mainly HTN, edema, <3 failure, and commonly in combo with a thiazide or loop diuretic.
-spironalactone counteracts the K-wasting effects of the more powerful diuretics
AE: hyperkalemia, benign and malignant tumors, endocrine effects (gynecomastia, menstrual irregularities, impotence, hirutism (excessive hair growth in women) and deepening of the voice)
5 True/False questions
Define antagonist → produce their effects by preventing receptor activation by endogenous regulatory molecules and drugs.
Has affinity, but not intrinsic activity
no receptor activation
Pseudoephredine (Sudafed) → indications: nasal decongestant, causes vasoconstriction of blood vessels in nose
AE: CNS stimulation (restlessness, irritability, anxiety), use cautiously in pts w/ HTN and CAD
Tetracyclines → indications:pain
AE: respiratory depression, bradycardia, allergic reactions, constipation
antidote: narcan, give colace for constipation
NSAIDs (buprofen) → an agent or factor that causes a malformation of an embryo.
1- drug must cause a characteristic set of malformations
2-must act only during a specific window of vulnerability (wks 4-7 of gestation)
3-incidence of malformations should increase with increasing dosage and duration of exposure
Propylthiouracil (PTU) → indications: treats streptococcus pneumonia and pyrogenes
AE: allergic reactions, pain at injection site, sensory/motor dysfunction, neurotoxicity if blood levels too high
*alternative = erythromycin