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Ch. 19 Cell Molec

Terms in this set (39)

The phase of the cell cycle is associated with the doubling of the amount of DNA in the cell is?
S
The phase of the cell cycle associated with the replication of DNA is?
interphase
In the cell cycle, a mitotic Cdk is present during?
G1, G2, M, S
Using polyethylene glycol (PEG), early G1 phase cells were fused with S phase cells. Of the following events, which would you expect to be induced in the G1 cells as a result of the fusion?
DNA replication
DNA replication is?
semiconservative
All of the following circular DNAs exhibit theta replication except?
protists
DNA replication requires?
a type of RNA polymerase
All of the following are associated with replicons except?
single-strand binding proteins
A NASA probe returned samples of rocks from the surface of Mars. From these rocks, a prokaryotic organism was isolated and remained viable under conditions similar to that of Mars. The organisms are capable of dividing to replicate themselves. In order to determine whether the DNA replication of these organisms was semiconservative, an experiment using N15/N14 (similar to that of Mendelson and Stahl) was performed. If the method of DNA replication were conservative, after one generation one would expect to see?
half of the DNA in the light band, the other half in the heavy band
An isolate of a mutant bacterium appears to grow more slowly than the population (wild type) from which it was isolated. Further studies showed that the slower growth was due to a markedly reduced DNA polymerase I activity. From this information, one would expect that this organism would also be deficient in the activity of DNA
excision repair
Which of the following statements regarding DNA replication is true?
bacterial replication is faster than eukaryotic replication
What is the ploidy of an organism that is 7n, where n=5?
7
During metaphase of mitosis, how many telomeres are present in a cell in which 2n=12?
48
In a cell with diploid number of 12, how many chromatids are present at prophase of mitosis?
24
Ultraviolet (UV) light-treated bacteria would most likely have DNA damage in the form of?
-thymine dimer formation
A particular strain of yeast produces strains with a mutant cdc2 gene, resulting in little to no production of the Cdc2 protein kinase. As a result, one would expect that these cells would
a) not enter M phase
b) not have the nuclear envelope disperse
c) lack chromosome condensation
d) all of the above
e) none of the above
D
A mutant strain of yeast possesses a mutation in the nda2 gene, resulting in no production of alpha1 tubulin. As a result, these cells would most likely
have little or no spindle formation
Cyclins modulate the progression of cells through the cell cycle by
activating protein kinases that are critical regulators of cell division
During the G2 checkpoint in eukaryotic cells, the cell is assessed with regard to
DNA replication
Which of the following proteins is observed exclusively in association with prokaryotic DNA replication?
DNA polymerase I
Which of the following eukaryotic DNA polymerases replicates mitochondrial DNA?
gamma
Which of the following proteins is observed exclusively in association with eukaryotic DNA replication?
telomerase
In order to be active, a Cdc-cyclin needs to be
singly phosphorylated
The longest phase of the cell cycle is
interphase
The phase of the cell cycle that varies most in duration in various cell types is
G1
The proteins most actively synthesized during the S phase of the cell cycle are
histones
In the cell cycle, controlled degradation of regulatory proteins occurs via the
ubiquitin-proteosome pathway
Which of the following would not inhibit a cell preparing to undergo mitosis?
Cdc-activating kinase activity
Phosphorylation of ____ is required for chromosome condensation
condensin
Which enzyme is involved in proofreading during DNA replication?
3' to 5' exonuclease
The multiple sites of DNA replication along eukaryotic chromosomes are known as?
replicons
The protein(s) that facilitate the unfolding of chromatin fibers ahead of the replication fork is (are)
chromatin remodeling proteins
DNA repair in eukaryotes that facilitates replication in regions of thymine dimers is mediated by a unique DNA polymerase
n- eta
Ras is to Raf, as MEK is to
MAPK
Which of the following families of proteins is associated with the contractile ring?
rho
Killer lymphocytes can elicit self-destruct mechanisms in target cells by interacting with
Fas receptors
Which of the following statements regarding Fas-mediated programmed cell death is false?
Fas ligand binding with Fas receptor stimulates a specific G protein
Mice lacking the ability to make caspase-9 die as the result of numerous defects. During the necropsy (animal autopsy) of the animal you note that the brains of these mice are
lack of apoptosis of some cells
All of the following participate in apoptosis except
Bcl-2
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