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Terms in this set (19)
Order of med choices for fibromyalgia
Try TCA first, then SSRI or SNRI, then anticonvulsant
What are TCAs, SSRIs, SNRIs, and anticonvulsants thought to do for pts w/ fibro?
May influence pain matrix, inducing changes in neuronal activity during the pain state
Is there one med option that works better than another?
No. Just pick the med that works best for the pt
What TCA is used for fibromyalgia?
Dosing of Amitriptyline
Dosed at bedtime. Start at low dose and titrate up
SE of amitriptyline
Dry eyes/mouth, constipation, wt gain
What med is used as an alternative to amitriptyline?
How does Cyclobenzaprine compare to Amitriptyline?
Has a similar tricyclic structure and similar mode of action in fibro, but no antidepressant effects
SNRIs used for fibromyalgia
SE of SNRIs
Nausea, dry mouth, headache
Anticonvulsants used for fibromyalgia
MOA of anticonvulsants
Have an effect on cellular calcium channels. May exert analgesic effects by blocking the release of various neurotransmitters such as glutamate and glutamine which are involved in the pain pathway
SE of anticonvulsants
Wt gain, dizziness, somnolence, peripheral edema, dry mouth
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