General HIV notes
Terms in this set (42)
two recommended 1 tab initiation regimens
crofelemer (Fulyzaq) 125 mg BID
NRTIs BBW for the whole class
Lactic acidosis and severe hepatomegaly
Which med requires HLA-B*5701 testing prior to therapy and why?
Abacavir (Ziagen) d/t severe hypersensitivity rxn
What is the only NRTI that does not require renal dosing?
which NRTIs should be avoided due to increased risk of pancreatitis, peripheral neuropathy and hyperlactatemia?
Diadanosine and stavudine
(Videx and Zerit)
300 mg BID
600 mg daily
200 mg daily
Which combo ART regimens can be taken one tab daily?
which NRTI regimen is preferred in pregnancy?
150 mg BID
300 mg daily
which two NRTIs should not be combined b/c there's no benefit?
lamivudine and emtricitabine
300 mg daily
which NRTI is available in IV form?
zidovudine (Retrovir) and is used in pregnancy during labor
which NRTI is associated with Fanconi syndrome?
Which HIV drug class does not undergo CYP metabolism and so has less DDIs?
what are common ADRs for the whole NNRTI class?
600 mg daily on empty stomach (best at bedtime)
which HIV drug is associated with CNS impairment, vivid dreams and psychiatric symptoms?
efavirenz is contraindicated with which meds?
St. John's Wort
why is nevirapine usually avoided?
severe hepatotoxic reactions, life-threatening skin reactions, 3A4 inducer
(cannot be initiated in women with CD4+ counts >250 and men with counts >400 d/t increased risk of hepatotoxicity)
which NNRTI is contraindicated with strong CYP inducers and PPIs?
rilpivirine (Edurant) also in Complera
Common ADRs for PI class:
immune reconstitution syndrome
300 mg daily (with 100 mg ritonavir)
which PI prolongs PR interval?
darunavir must be _____
boosted with ritonavir
which PI may cross-react with sulfa allergy?
100-400 mg daily (booster dose)
which PI should NOT be boosted d/t increased risk of toxicity?
which PI can prolong QT and PR intervals?
saquinavir (s/b avoided)
which HIV med is administered SC?
90 mg SC BID
which HIV med requires tropism test?
400 mg BID
(without regards to meals)
50 mg daily
which INSTI should not be used in pt <40 kg?
which HIV med can be taken as pre-exposure prophylaxis?
Truvada 1 tab PO daily
which regimen is usually used for occupational exposure prophylaxis?
Truvada x 4 weeks
PRIMARY prophylaxis can be used for which opportunistic infections?
When should PCP prophylaxis begin?
CD4 <200 or oropharyngeal candidasis
(Septra or dapsone)
When should toxo prophylaxis begin?
toxo IgG positive with CD4 <100
(septra or dapsone)
when should MAC prophylaxis begin?
(azithromycin 1,200 mg PO weekly or clarithromyccin)
which HIV med may cause darkening of skin on palms and feet?
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