Insulin is a protein that is produced by pancreatic cells and secreted into the bloodstream. Which of the following options correctly lists the order of the structures through which insulin passes from its production to its exit from the cell?
A) rough ER, lysosomes, transport vesicles, cell membrane
B) rough ER, transport vesicles, Golgi apparatus, transport vesicles, cell membrane
C) rough ER, Golgi apparatus, smooth ER, cell membrane
D) rough ER, transport vesicles, Golgi apparatus, vacuole, cell membrane
E) rough ER, transport vesicles, cell membrane