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Immunology Ch 9
Terms in this set (16)
Epitope-specific TCRs and BCRs are randomly generated by __ __.
self-reactive lymphocytes undergo ___.
B -1 Cells:
transitional - develop earlier- mature cells in peritoneum and lungs
adaptive immunity- longer to develop- conventional B cell
T cell precursors = __. __ enter cortical region, lacking TCR, CD3, 4 & 8.
When T cells arrive at thymus they aren't technically T cells. They can go on to be: . The receptor ___ commits them to the T lineage by activating the ____ transcription factor.
dendritic, B cells, myeloid cells, etc.
Notch; Gata -3
ab T Cell development:
1. Prothymocytes arrive in bone marrow as __.
2. DN proliferate into __ expressing:
3. Recognition of ___. This is called ___.
4. Survival of positive selection -> thymocytes now express only __ or __ _ CD3 & TCR.
5. too strong of MHC interactions undergo apoptic death-___ ___.
6. Mature __ __ thymocytes cross the endothelium of a venule and exit the thymus as T cells.
DP -> all CD's
MHC I or II ->positive selction
CD4 or CD8
VERY early thymocyte development occurs in the __ __. cells migrate to the __ for further development. Recombination of TCR gene segments also occurs in the __stages, yielding either an αβ or a γδ T cell
bone marrow ; thymus ; DN
Positive selection - must bind to __.
Negative selection - __ of cells that interact with antigen-presenting cells (self)
If pass both selections, become __ and leave thymus
MHC; removal; T cells
y5 T cell development - do not undergo same process as aB. Migrate to: ___. Respond ___. No ___.
respiratory organs, skin, peritoneal cavity; ; qucikly; memory
NKT cells - express TCRs- limited in ___ to lipids, glycolipids, and some specialized peptides; They recognize nonclassical MHC 1 molecules ( ___ )
apoptosis occurs with triggering ___.
In B cell development only __ selection is required.
B cell maturation / development characteristics
pre-pro B cell:
Pro - B Cell :
late Pro - B Cell/ early pre - B cell:
Late Pre - B cell:
Immature B cell:
Mature B cell:
Iga & Igbeta
u heavy chain
u heavy chain + SLC
rearrangement of k or lambda light chain
exit bone marrow (IgM)- enter into perifpherary
Coepress IgM and IgD in lymphnodes
3 Stages of B cell development and what stage is antigen independent?
Maturation ( antigen independent): generation of immunocompetent B Cells
Activation: interaction with antigen
Differentiation: plasma and memory cells
B2 Cell characteristics -
Require interaction with __ for activation and proliferation
Continually replaced from ___ ___
Repeated antigen exposure = stronger, faster response
Often accompanied by class ___
More __expressed than IgM
B1 Cell characteristics -
B-1 - arise from fetal __
Importance in ___and autoimmunity
Often directed against conserved microbial antigens (carbohydrates)
Most natural ___
Predominantly in areas of microbial entry
B and T cell differences:
B cells use negative while T cells use __ .
T cells require __ and differentiate into __ or __ subsets.
B cells require __ __ and secrete antibodies.
+ and -
presentation; helper or killer
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