NONRECIPROCAL chromosomal translocation that commonly involves chromosome pairs 13, 14, 15, 21, 22. One of the most common types of translocation.
Occurs when the long arms of 2 acrocentric chromosomes (chromosomes with centromere near their ends) fuse at the centromere and the 2 short arms are lost.
Balanced translocation normally do not cause any abnormal phenotype.
Unbalanced translocations can result in miscarriage, still birth, and chromosomal imbalance (e.g. Down syndrome, Patau's syndrome)