Upgrade to remove ads
Metabolism and Excretion
Terms in this set (21)
Most biotransformation occurs in the _____.
Results of Biotransformation:
-activate an inactive drug
-inactivate an active drug
-convert active drug to active metabolite
-convert active drug or metabolite to toxic metabolite
metabolites are usually more polar, H20 soluble, excreted faster than parent drug
What is in phase I of chemical transformation?
What is in phase II of chemical transformation?
microsomal enzymes refer to ____
are microsomal enzymes inducible?...in other words, can we make more if we need them?
non-microsomal enzymes are located where?
cytosol, mitochondria, and plasma
are non-microsomal enzymes inducible?...in other words, can we make more if we need them?
2 microsomal enzymes
NADPH-cytochrome P450 reductase
Cytochrome P450 (CYP or P450)
What is the location of NADPH-cytochrome P450 reductase and Cytochrome P450 (CYP or P450)?
smooth ER of most cells. abundant in the liver
what family its in
4 things needed for a p450 oxidation reaction?
-NADPH-cytochrome P450 reductase (a flavoprotein)
-Cytochrome P450 (serves as the terminal oxidase)
-NADPH (the reducing agent)
-Nicotinamide adenine dinucleotide phosphate
Factors that influence the rate of biotransformation:
Enzyme inducers (smoking, environmental agents, drugs)
Enzyme inhibitors (competing drugs)
Major routes of drug excretion?
Pulmonary (exhalation) excretion
Minor routes of drug excretion?
-Sweat and saliva
More chemicals are eliminated from the body by this route than by any other?
THIS SET IS OFTEN IN FOLDERS WITH...
Principles of Pharmacology Part 1
Principles of Pharmacology Part 2
Absorption & Distribution of Drugs and Toxicants
YOU MIGHT ALSO LIKE...
Drug action exam 2 (part I)
Pharmacology - Pharmocokinetics
Intro to Pharm
OTHER SETS BY THIS CREATOR
Law Ch. 4
Law Chapter 3
Law Chapter 2
Chapter 1: Law and the Legal System