Protracted proton pump inhibitor (PPI) use is associated with reduced, rather than increased, absorption of iron, copper, vitamin B12, and other micronutrients in the elderly.
An increase in fracture risk of the hip, spine, wrist, and forearm has been noted with long-term PPI use. Individuals with multiple health problems, when hospitalized or in long-term care, who are online chronic PPI therapy have an increased risk of contracting pneumonia and of developing C. difficile colitis.
Myeloma is a cancer of the plasma cells (or mature B-cells/lymphocytes), which affects the bone marrow. Plasma cells produce antibodies and reside mainly in the bone marrow. Signs/symptoms are bone pain, fractures, hypercalcemia, depressed immunity, and anemia. The bone marrow produces WBCs (neutrophils, lymphocytes, eosinophils, basophils), RBCs, and platelets. The typical patient is an older adult who is aged 60 years or older. If symptoms of a transient ischemic attack persist beyond 24 hours, the diagnosis of a stroke should be considered.
A transient ischemic attack (TIA) is an acute neurological event in which all signs and symptoms, including numbness, weakness, and flaccidity, visual changes, ataxia, or dysarthria, resolve usually within minutes, but certainly by 24 hours after onset. If changes persist beyond 24 hours, the diagnosis of stroke should be considered.