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24 terms

Adverse Reactions

STUDY
PLAY
Penicillins
ALLERGIC REACTIONS (anaphylaxis, urticaria, drug fever)
GI (NVD, Pseudomembranous colitits, C. difficile
HEMATOLOGIC
NEUROLOGIC (seizures at high doses)
Cephalosporins
ALLERGIC REACTIONS (anaphylaxis, urticaria, drug fever)
GI (NVD, Pseudomembranous colitis)
HEMATOLOGIC
NEUROLOGIC
DISULFIRAM-LIKE REACTION (methylthiotetrazole side chain)
Carbapenems
Infusion site problems
Nausea and vomiting (imipenem infusion)
Diarrhe: high risk of C. difficile due to broad spectrum
ALLERGIC REACTIONS - cross reaction with penicillins higher than cephalosporins
SEIZURES with Imipenem
Monobactam (Aztreonam)
Injection site reactions
rash
NVD
WEAKLY IMMUNOGENIC
Aminoglycosides
MAJOR
- Nephrotoxicity, Ototoxicity, & Neuromuscular Blockade
Minor
- drug fever, rash
Trimethoprim-Sulfamethoxazole
HYPERSENSITIVITY REACTIONS (fever & rash)
Renal
- CAN CRYSTALLIZE AND CAUSE STONES IF NOT HYDRATED
Hematologic
- BONE MARROW SUPPRESSION COMMON AT HIGH DOSES
Tetracyclines
PHOTOSENSITIVITY
DISCOLORATION OF DEVELOPING TEETH
hepatotoxicity
ESOPHAGEAL ULCERATION
GI upset
Skin discoloration
Tigecycline
NAUSEA AND VOMITING (20-30%)
diarrhea
Cross reactivity with tetracyclines
Macrolides
NOTABLE NAUSEA
abdominal pain, metallic taste, headache, and transient hearing loss
Quinolones
GI, CNS effects, Hepatic, Photosensitivy, Tendonitis
QT interval prolongation (CAUTION WITH OTHER MEDS THAT PROLONG QT)
Clindamycin
DIARRHEA
C. difficile colitis
GI UPSET
rare hypersensitivity reactions
Metronidazole
CNS EFFECTS
GI UPSET
METALLIC TASTE
Dark urine
DISULFIRAM-LIKE REACTION
Chloramphenicol
APLASTIC ANEMIA (irreversible)
BONE MARROW SUPPRESSION(reversible)
GRAY BABY SYNDROME (primarily neonates)
CNS effects, GI symptoms, CYP-450 inhibition
Vancomycin
NEPHROTOXICITY
Ototoxicity
DRUG FEVER
INFUSION-RELATED SIDE EFFECTS (redman syndrome & hypotension)
Thrombophlebitis
Hypersensitivy reactions
Neutropenia/bone marrow suppression
Quinupristin/Dalfopristin
INFLAMMATION AT INFUSION SITE
ARTHRALGIA/MYALGIA Not compatible with saline
Hepatotoxicity, GI upset, Rash/itching, Inhibits CYP450 3A4
Linezolid
THROMBOCYTOPENIA(usually after 2 weeks)
diarrhea, headache, nausea, lactic acidosis, perpheral & optic neuropathies
Daptomycin
MYOPATHY, monitor CPK weakly
nausea, diarrhea, comiting, and constipation
Oseltamivir
Nausea, abdominal discomfort, vomiting
Headache
No significant drug interactions
Zanamivir
Breezing and bronchospasm
- not recommended for treatment of patients with underlying airway disease
No drug interactions reported
Amantadine
CNS: minor and resolve despite continuation of therapy (More severe in patients with decreased renal function)
Tremors/Parkinsonian patients
depression, orthostatic hypotension, psychosis, urinary retention, and CHF
GI: nausea, diarrhea, constipation, anorexia
Isoniazid
Peripheral neuritis, CNS side effects
Hepatotoxicity
Allergic reactions
Drug interaction w/ alcohol and aluminum-containing antacids
Rifampin
MAY GIVE A RED-ORANGE COLOR TO URINE, FECES, SALIVA, SWEAT, and TEARS
headache, drowsiness, ataxia, dizziness, fatigue
Anorexia, nausea, mild abdominal comfort, diarrhea
Hepatitis (especially in alcoholics)
Ethambutol
Occasionally mild GI upset, abdominal pain, allergic reactions
Retrobulbar neuritis (dose related)
Peripheral neuropathy
Pyrazinamide
Flushing
Mild nausea and anorexia
Renal failure - hyperuricemia
Liver injury
Arthralgia