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the Potency inhalation anesthetic increases in direct proportion to their Partition Coefficient between oil and water
All inhalation agents share a common mechanism of action.
Critical Volume Hypothesis
Mullins hypothesized that anesthesia occurs when the absorption of anesthetic molecules expands the volume of a hydrophobic region beyond a critical amount (critical volume hypothesis).
When the drug fits the shape of the active site of the receptor, a complex is formed which causes altered cell activity.
Supraspinal effects, Spinal Cord, Thalamus and Midbrain