6 terms

Anesthesia Hypotheses

Meyer-Overton Rule
the Potency inhalation anesthetic increases in direct proportion to their Partition Coefficient between oil and water
Unitary Hypothesis
All inhalation agents share a common mechanism of action.
Critical Volume Hypothesis
Mullins hypothesized that anesthesia occurs when the absorption of anesthetic molecules expands the volume of a hydrophobic region beyond a critical amount (critical volume hypothesis).
Membrane Hypothesis
Receptor Theory
When the drug fits the shape of the active site of the receptor, a complex is formed which causes altered cell activity.
Supraspinal effects, Spinal Cord, Thalamus and Midbrain