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Meyer-Overton Rule

the Potency inhalation anesthetic increases in direct proportion to their Partition Coefficient between oil and water

Unitary Hypothesis

All inhalation agents share a common mechanism of action.

Critical Volume Hypothesis

Mullins hypothesized that anesthesia occurs when the absorption of anesthetic molecules expands the volume of a hydrophobic region beyond a critical amount (critical volume hypothesis).

Membrane Hypothesis


Receptor Theory

When the drug fits the shape of the active site of the receptor, a complex is formed which causes altered cell activity.

Supraspinal effects, Spinal Cord, Thalamus and Midbrain


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