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19 terms

Biochem Unit 2 Eb2834

STUDY
PLAY
PDH E1
Pyruvate DH + TPP
PDH E2
Dihydrolipoyl Transacetylase + Lipoic acid (lipoate)
PDH E3
Dihydrolipoyl DH + FAD
Permanent cofactors of PDH
TPP
Lipoate
FAD
Non-permanent cofactors of PDH
CoA-SH
NAD+
Inhibitors of PDH (4)
ATP
Acetyl-CoA
NADH
Fatty Acids
Stimulators of PDH (4)
AMP
CoA
NAD+
Ca2+
Inhibitors of Citrate Synthase (4)
NADH
Succinyl-CoA
Citrate
ATP
Stimulator of citrate synthase (1)
ADP
Inhibitors of Isocitrate Dehydrogenase (2)
ATP
NADH
Stimulators of isocitrate dehydrogenase (2)
Ca2+
ADP
Inhibitors of a-ketoglutarate dehydrogenase complex (2)
succinyl-CoA
NADH
Stimulators of a-ketoglutarate DH complex (1)
Ca2+
Redox Carriers
Nicotinamide and Flavin e- carriers
Ubiquinone
Heme
Iron-sulfur clusters
3 Fates for Glucose
Storage in glycogen
Oxidation to ribose-5-phosphate
Oxidation to pyruvate
Two in vivo sources of glucose
Mobilization from glycogen
REduciton of non-carb precursors to gluconeogenic substrates
Carbon sources for gluconeogenesis
Lactate
Amino acids (alanine)
Glycerol
Proprionate
3 Tissues active in gluconeogenesis
Liver (principal)
Kidney Cortex
Skeletal Muscle
Reactive Oxygen Species
Singlet oxygen
Superoxide radical anion
Hydrogen peroxide
Lipid peroxyl radical
hydroxyl radical