Dihydrolipoyl Transacetylase + Lipoic acid (lipoate)
Dihydrolipoyl DH + FAD
Permanent cofactors of PDH
Non-permanent cofactors of PDH
Inhibitors of PDH (4)
Stimulators of PDH (4)
Inhibitors of Citrate Synthase (4)
Stimulator of citrate synthase (1)
Inhibitors of Isocitrate Dehydrogenase (2)
Stimulators of isocitrate dehydrogenase (2)
Inhibitors of a-ketoglutarate dehydrogenase complex (2)
Stimulators of a-ketoglutarate DH complex (1)
Nicotinamide and Flavin e- carriers
3 Fates for Glucose
Storage in glycogen
Oxidation to ribose-5-phosphate
Oxidation to pyruvate
Two in vivo sources of glucose
Mobilization from glycogen
REduciton of non-carb precursors to gluconeogenic substrates
Carbon sources for gluconeogenesis
Amino acids (alanine)
3 Tissues active in gluconeogenesis
Reactive Oxygen Species
Superoxide radical anion
Lipid peroxyl radical
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