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autoantibodies and the associated conditions

antimitochondrial antibody (+antinuclear factor, and raised IgM)

Primary Biliary Cirrhosis

anti-smooth muscle antibody (+ raised IgG)

chronic active hepatitis

raised IgA

alcoholic liver disease



anti-Sm, anti-Ro, anti-La


anti-Scl 70 anti-centromere

CREST variation of systemic sclerosis


assoc with heart block in neonates whos mums have it



Rf, anti-Ro, anti-La


RF definition

IgM antibody for the Fc portion of IgG


not specific for RA, 30% SLE, 90% Sjorens

RF also occurs in

Sarcoid and any other condition that stimulates IgG production

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