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35 terms

lab stats

1
STUDY
PLAY
accuracy
measured v. true value
analytical variation: how to know if therapy changed lab? examples?
how to see if therapy changed lab, 3SD between 1st and subsequent msmt=95% confident; hemolysis, lipidemia, ictonic
effect of hemolysis on lab values
decrease Na+, increase K+, trans ALT, folates
intraindividual var cause
hydration, food intake, activity, stress, posture, circadian rhythm
interindividual variation
age, sex, diet, body mass, activity level, genetics
-PV
TN/(TN+FN)
+PV
TP/(TP+FP)
sensitivity
disease pop, TP/(TP+FN)
specificity
healthy pop, TN/(TN+FP)
sources of variation
hemolysis, drugs
barbituate effect on bilirubin
decrease because glucaronic transferase induced
drugs causing liver toxicity effect on bilirubin
increase bilirubin values
opiates effect on amylase
increase amylase values
quinidine effect on serum digoxin
increase because quinidine releases digoxin from heart muscle and decreases renal clearance
establish reference ranges gaussian
2SD+/- mean
establish reference ranges non-gaussian
inner 95% fo population
alkaline phosphatase results in kids
increase
ammonia results in kids
increase
AST results in kids
increase
bilirubin results in kids
increase
CK results in kids
increase
K+ results in kids
increase
GGT results in kids
gammy glutanyl transferase increase
TSH, T4 results in kids
increase
bicarbonate results in kids
decrease
albumin results in kids
decrease
creatinine results in kids
decrease
amylase results in kids
decrease
cholesterol results in kids
decrease
copper results in kids
decrease
glucose results in kids
decrease
haptoglobin results in kids
decrease
igA,E,M osmolality results in kids
decrease
why do lab techs use controls
Controls distinguish between random variation (inevitable) and systemic error (2x SD)
precision expressed as SD an coef of variation
coef of var= (sd/mean), sd= sqrt variance