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5 Written questions

5 Matching questions

  3. CIPROFLOXACIN Nursing implications -
  5. CEFUROXIME Action -
  1. a Binds to bacterial cell wall membrane, causing cell death; Bactericidal action against susceptible bacteria. Similar to that of first-generation cephalosporins but has increased activity against several other gram-negative pathogens
  2. b Inhibits bacterial DNA synthesis by inhibiting DNA gyrase enzyme.; Death of susceptible bacteria; Active against gram-positive pathogens, including.
  3. c Appendicitis and peritonitis, Skin and skin structure infections, Gynecologic infections, Community-acquired and nosocomial pneumonia caused by piperacillin-resistant, beta-lactamase-producing bacteria.
  4. d Action - Inhibits bacterial DNA synthesis by inhibiting DNA gyrase enzyme.; Death of susceptible bacteria; Active against gram-positive pathogens, including. › Staphylococcus aureus.
    › Staphylococcus epidermidis.
    › Staphylococcus saprophyticus.
    › Streptococcus pyogenes.
    › Streptococcus pneumoniae.
    › Enterococcus faecalis.
    › Bacillus anthracis (anthrax).
    • Gram-negative spectrum notable for activity against. › Escherichia coli.
    › Klebsiella pneumoniae.
    › Enterobacter cloacae.
    › Salmonella typhi.
    › Shigella spp.
    › Proteus mirabilis.
    › Proteus vulgaris.
    › Providencia stuartii.
    › Providencia rettgeri.
    › Morganella morganii.
    › Pseudomonas aeruginosa.
    › Serratia marcescens.
    › Haemophilus influenzae.
    › Neisseria gonorrhoeae.
    › Moraxella catarrhalis.
    › Campylobacter jejuni.

    Use- PO, IV: Treatment of the following bacterial infections. › Urinary tract and gynecologic infections, including cystitis, gonorrhea, and prostatitis.
    › Respiratory tract infections including acute sinusitis, acute exacerbations of chronic bronchitis, and pneumonia.
    › Skin and skin structure infections .
    › Bone and joint infections .
    › Infectious diarrhea .
    › Complicated intra-abdominal infections (with metronidazole).
    › Typhoid fever.
    • Post-exposure prophylaxis of inhalational anthrax.
    • Cutaneous anthrax.

    Side Effect - Seizures, dizziness, drowsiness, headache, insomnia, agitation, confusion, d/n/r , pseudomembranous colitis, abdominal pain, abnormal liver enzymes, vaginitis, photosensitivity, hyperglycemia, hypoglycemia, eosinophilia, phlebitits at IV site, tendinitis, tendon rupture, peripheral neuropathy, anaphylaxis

    Contraindictions - Hypersensitivity (cross-sensitivity within class may exist).
    • OB: Do not use unless potential benefit outweighs potential fetal risk.
    • Pedi: Use only for treatment of anthrax and complicated urinary tract infections in children 1-17 years due to possible arthropathy.

    Nursing implications - PO on empty stomach ; intermittent infusion; observe for s/s of anayphylaxis, monitor bowel function

    Trade / Generic Name - Cipro, Cipro XR, Proquin XR

    Classification - Fluoroquinolones; anti-infectives

    Dosage: PO 500-750 mg q 12hrs
    IV 400 mg q 12 hrs
  5. e PO on empty stomach ; intermittent infusion; observe for s/s of anayphylaxis, monitor bowel function

5 Multiple choice questions

  1. Inhibits protein synthesis in bacteria at level of 30S ribosome; Bactericidal action; Notable for activity against. ›
  2. Previous hypersensitivity to penicillin
  3. - d/n/v/r/ constipation, drug induced hepatitis, confusion dizziness, headache, insomnia, lethargy, interstitial nephritis, bleeding ,leucopenia, neutropenia, thrombocytopenia, pain, phlebitis at IV site; hypersensitivity reactions, serum sickness, fever(increase in cystic fibrosis patients), superinfection
  4. - Administer IV / IM = Penicillin G; PO = Penicillin V ; Observe for s/s anaphalxis
  5. intermittent infusion ; s/s of anaphylaxis

5 True/False questions

  1. OXACILLIN Action -Binds to bacterial cell wall, causing cell death; bactericidal action; spectrum is broader than penicillins


  2. CEFTRIAXONE Nursing implications-Nursing implications - PO, admin with food; IM/IV, Direct IV, Intermittent infusion


  3. CEFAZOLIN Contraindictions -Hypersensitivity to cephalosporins. Serious hypersensitivity to penicillins


  4. AMOXICILLINAction - Bind to bacterial cell wall, resulting in cell death; Broad spectrum

    Use - skin & skin structure infections, soft-tissue infections, otitis media, sinusitis, respiratory infections, genitourinary infections, meningitis, septicemia. Endocarditis prophylaxi

    Side Effect - Seizures(high doses) pseudomembranous colitis, d/n/v/r, urticaria, blood dysrasias, anaphylaxis serum sickness, superinfection

    Contraindictions - hypersensitivity to penicillins

    Nursing implications - IM / IV use for moderately severe to severe infections; change to PO asap; s/s anaphylaxis & monitor bowl functions

    Trade/Generic Name - Marcillin, Omnipen, Penbritin, Principen, Polycillin, Totacillin

    Classification - Aminopenicillins; anti-infectives

    Dosage: PO 250-500mg q 6hrs
    IM/IV 500mg to 3gm q 6hrs


  5. AUGMENTIN (Amoxicillin/Clavulanate)Action- Binds to bacterial cell wall, causing cell death; spectrum of amoxicillin is broader than penicillin. Clavulanate resists action of beta-lactamase, an enzyme produced by bacteria that is capable of inactivating some penicillins; Bactericidal action against susceptible bacteria(Active against Streptococci. Pneumococci. › Enterococci. Haemophilus influenzae. Escherichia coli. Proteus mirabilis Neisseria meningitidis. N. Gonorrhoeae. Staphylococcus aureus Klebsiella pneumoniae. Shigella Salmonella. Moraxella catarrhalis

    Use- Skin and skin structure infection Otitis media, Sinusitis Respiratory tract infections, Genitourinary tract infections.

    Side Effect - d/v/n/r urticaria, seizures(high doses) pseudomembranous colitis, hepatic dysfunction, vaginal candidiasis, blood dycrasias, allergic reactions including anaphylaxis & serum sickness, superinfection

    Contraindictions - Hypersensitivity to penicillins or clavulanate, Suspension and chewable tablets contain aspartame and should be avoided in phenylketonurics; History of amoxicillin/clavulanate-associated cholestatic jaundice.

    Nursing implications - PO(Administer at the start of a meal to enhance absorption and to decrease GI side effects. Do not administer with high fat meals; clavulanate absorption is decreased.)

    Trade/ Genetric Name - Amoclan, Augmentin, Augmentin ES, Augmentin XR

    Classification - aminopenicillins beta lactamase inhibitors; anti-infectives

    Dosage: PO 250mg q 8hrs
    500mg q 12hrs