Most common: headache, dyspepsia
Elevations of serum hepatic transaminase (ALT); monitor enzyme levels. Reversible.
Rare- Eosinophilic vasculitis (Churg-Strauss syndrome), particularly when corticosteroids are reduced.
BLACK BOX: antileukotrienes associated with increase neuropsychiatric events (rare)
(agitation, aggression, anxiousness, dream abnormalities, insomnia, hallucinations, depression, irritability, suicidal thinking and behavior, tremors, etc)
Zafirlukast and Zileuton inhibit P-450 enzymes.
Both increase serum warfarin and theophylline levels.
Zafirlukast decreases serum eryhtromycin
Atopy (tendency to be hyperallergic)- strongest predisposing factor
Nonspecific precipitants: exercise, URIs, rhinitis, sinusitis, postnasal drip, aspiration, gastroesophageal reflux, changes in the weather, and stress.
Pollutants and cigarette smoke can cause asthma
For some people - aspirin, NSAIDs, or tartrazine dyes