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Lecture Section - Erythrocytes - Part I - Six Stages of Erythrocytes

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Six stages of erythrocyte development
1. Rubriblast
2. Prorubricyte
3. Rubricyte
4. Metarubricyte
5. Reticulocyte
6. Mature erythrocyte
Rubriblast
also known as Pronormablast or Proerythroblast
Rubriblast
earliest recongnizable red cell precursor
Rubriblast
originates from a commited stem cell which orginated from a pluripotential stem cell
Rubriblast
each pronormoblast produces 8-16 mature red cells
Rubriblast
large round cell, 12-20 micro in diameter
Rubriblast
high nuclear cytoplasm ratio (N:C)
Rubriblast
large reddish-purple nucleus and small amount of deeply basophilic cytoplasm
Rubriblast
chromatin is very fine and "lacy" in appearance
Rubriblast
has one or more nucleoli
Rubriblast
perinuclear halo - clearing around the nucleus - represents mitochondria
Rubriblast
hemehlobin synthesis may begin at this stage but its presence is generally obsucred because of the large nuber of ribosomes
Rubriblast
upon specific stimulation, divides and matures and gives rise to two prorubricytes
Prorubricyte
also known as basophilic normoblast or basophilic erythroblast
Prorubricyte
smaller than rubriblast, 10-16 micro in diameter
Prorubricyte
N:C is decreased
Prorubricyte
more abundant cytoplasm, usually deeply basophilic
Prorubricyte
hemeglobin synthesis may cause areas of pinkish cytoplasm to appear
Prorubricyte
nuclear chromatin becomes coarser
Prorubricyte
majority of hemeglobin is made in this stage
Rubricyte
also known as polychromatophilic normoblast or polychromatophilic erythroblast
Rubricyte
generally 10-12 micro in diameter
Rubricyte
further decreases in N:C ratio
Rubricyte
cytoplasm shows variable amounts of pink coloration mixed with basophilia; can give cell a grey-blue appearance
Rubricyte
large amounts of hemeglobin synthesized in this stage
Rubricyte
last stage capable of mitosis
Metarubricyte
also known as orthochromatophilic normoblast
Metarubricyte
8-12 micro in diameter
Metarubricyte
chromatin is tightly condensed and is described as pyknotic
Metarubricyte
cytoplasm is predominantly pink or salmon pink-indicates presence of large quantities of hemoglobin
Metarubricyte
also has blue-grayish tinge because of RNA
Metarubricyte
nuclear chromatin that is pyknotic is metabolically inactive/dead
Reticulocyte
also known as polychromatophilic erythrocyte
Reticulocyte
young erythrocyte without a nucleus
Reticulocyte
contains residual RNA and mitochondria in cytoplasm which gives cell a bluish tinge on a Wright stain
Reticulocyte
8-10 micro in diameter
Reticulocyte
part of this phase occurs in the bone marrow, later part takes place in circulating blood
Mature erythrocyte
binding, transport, and release of O2 is passive (don't need energy)
Mature erythrocyte
stains pink to orange due to large amount of hemoglobin
Mature erythrocyte
about 7 micro in diameter
Mature erythrocyte
cell has lost all residual RNA and mitochondria, therefore, is incapable of synthesizing new protein or lipid
Mature erythrocyte
normal life span is about 120 days
Mature erythrocyte
has limited metablosim due to absence of nucleus, mitochondria, and other subcellular organelles