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Terms in this set (21)
describe the structure of Hb
2 alpha and 2 beta tetramer bonded with 4 heme groups
What are the similarities between myoglobin and Hb
same primary structure with the same globin fold
Describe myoglobin's structure, function, and location
Mb is a monomer that stores O2 and is found in muscle tissue
Describe Hb's structure function and location
Hb is a tetramer, transports O2 and is found in RBC's
Describe Mb vs Hb's oxygen dissociation curve
Mb- hyperbolic, Hb- sigmoidal
What conformational change does oxygen binding cause in Hb
Causes Fe to move back into plane making the bonds between dimers stronger
What does 2,3 BPG do?
decreases Hb O2 affinity promoting the release of O2 from Hb
What type of change does 2,3 BPG cause in the oxygen dissociation curve
Increased 23BPG causes a right shift
Describe the pathway in glycolysis in which 2,3 BPG is involved
Hexokinase -> 2,3 BPG -> Pyruvate Kinase
How does a Pyruvate kinase deficiency affect O2 affinity
PK deficiency = more 2,3 BPG = right shift = decreased O2 affinity
How does a hexokinase deficiency affect O2 affinity
HK deficiency = less 2,3 BPG = left shift = increased O2 affinity
How does the storage of blood affect O2 affinity
The addition of Iosine as a preservative of blood causes a increase in O2 affinity of Hb causing less of the O2 to be released to the tissues.
how does pH affect O2 affinity?
High pH = high O2 affinity
at the lungs, describe how 2,3 BPG affects O2 affinity of Hb
release of 2,3 BPG from the Hb as O2 binds to Hb causing an increase in affinity for O2
at tissues, describe how 2,3 BPG affects the O2 affinity of Hb
Hb binds to 2,3 BPG which promotes the release of O2 from Hb
Which type of Hb maintains a high O2 affinity and a cherry red appearance?
Why can a person with anemia with Hb function reduced by 50% live, but a person with 50% of Hb O2 binding sites will be near death?
Because the person with only 50% of binding sites has such a high affinity for O2 that the Hb is NOT releasing the O2 into the tissues.
What disorder is carboxyhemoglobin associated with
Describe the mutation in the DNA that causes sickle cell
Position 6- Glutamic acid - valine
What is the protein associated with sickle cell mutation
How does HbS affect blood oxygen
mutation affects shape of cells and oxygen affinity thus preventing RBCs from getting the oxygen to the tissues as efficiently
THIS SET IS OFTEN IN FOLDERS WITH...
Biochem-Acid Base Disorders
Biochem- Amino Acids and Proteins
Biochem- Enzymes 1 and 2
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