chondrocytes in the center of hyaline cartilage enlarge & form struts which begin to calcify. Then the enlarged chondrocytes die, leaving cavities in the cartilage
Blood vessels grow around the edges of cartilage; cells in the perichondrium change to osteoblasts, producing a layer of superficial bone around the shaft which will continue to grow & become compact bone (appositional growth)
Blood vessels enter the cartilage, bringing osteoblasts, spongy bone develops at the primary ossification center
Remodeling creates a marrow cavity, bone replaces cartilage at the metaphyses
Capillaries & osteoblasts enter the epiphyses, creating secondary ossification centers
Epiphyses fill with spongy bone, cartilage remaining within the joint cavity is the articulation cartilage (Hyaline cartilage only in this phase)
Zone of resting cartilage
small scattered chondrocytes
Zone of proliferation
chondrocytes enlarge & divide
Zone of hypertrophy
chondrocytes are further enlarged
Zone of calcified cartilage
degeneration & death of chondrocytes
enlarges - width of bone
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