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A set of rules developed for establishing the relationship between a cause and a disease (4 total)
Koch's Postulate Rule 3
The agent must reproduce the disease when introduced into experimental animals
Predisposing Cause of Disease
Render the animal more susceptible to a specific disea without actually causing it
Exposure to Disease Examples
Contaminants/Physical agents (radiation, poisons), dose dependent and infectous agents
Innate vs. acquired; greater exposure means greater chance defense mechanisms will fail; compromised individuals will have lowered resistance
Causes of Cellular Injury
Hypoxia, physical agents, chemical agents, drugs, infectious agents, immunologic reactions and genetic derangements
Can cause cell injury; inflammation - responses to infections that cause collateral damage
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