Pharm - CNS - Muscle Spasm and Spasticity

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CNS - Muscle Spasm and Spasticity

baclofen (Lioresal)

Baclofen relaxes the back!
suppress hyperactive reflexes, acts on spinal cord (CNS), mechanism of action is unknown

baclofen (Lioresal)

i. multiple sclerosis
ii. spinal cord injury
iii. cerebral palsy

baclofen (Lioresal)
Side Effects

i. drowsiness, dizziness, weakness, fatigue
ii. N, constipation, urinary retention

baclofen (Lioresal)
Nursing Implications

i. assess for spasms, pain, ROM, rigidity
ii. avoid alcohol and CNS depressants
iii. withdraw over 1-2 weeks

dantrolene (Dantrium)

Dan (Dantrolene) and Pam (Diazapam) have a bad back.
Dantuine is hot and the atmosphere is bad for the liver!
acts directly on skeletal muscles to ↓spasticity, often associated with a significant
decrease in strength (evaluate positive vs. negative effects)

dantrolene (Dantrium)

i. multiple sclerosis
ii. spinal cord injury
iii. cerebral palsy
***also malignant hyperthermia

dantrolene (Dantrium)
Side Effects

i. hepatotoxicity - can be fatal
ii. muscle weakness
iii. drowsiness, diarrhea

dantrolene (Dantrium)
Nursing Implications

i. monitor LFTs (hepatotoxicity)
ii. assess muscle strength decline
iii. administer in the lowest dose in shortest duration
iv. avoid alcohol and CNS depressants
v. give with food

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