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Pharm - CNS - Muscle Spasm and Spasticity

CNS - Muscle Spasm and Spasticity
STUDY
PLAY
baclofen (Lioresal)
Baclofen relaxes the back!
suppress hyperactive reflexes, acts on spinal cord (CNS), mechanism of action is unknown
baclofen (Lioresal)
Indications
i. multiple sclerosis
ii. spinal cord injury
iii. cerebral palsy
baclofen (Lioresal)
Side Effects
i. drowsiness, dizziness, weakness, fatigue
ii. N, constipation, urinary retention
baclofen (Lioresal)
Nursing Implications
i. assess for spasms, pain, ROM, rigidity
ii. avoid alcohol and CNS depressants
iii. withdraw over 1-2 weeks
dantrolene (Dantrium)
Notes
Dan (Dantrolene) and Pam (Diazapam) have a bad back.
Dantuine is hot and the atmosphere is bad for the liver!
acts directly on skeletal muscles to ↓spasticity, often associated with a significant
decrease in strength (evaluate positive vs. negative effects)
dantrolene (Dantrium)
Indications
i. multiple sclerosis
ii. spinal cord injury
iii. cerebral palsy
***also malignant hyperthermia
dantrolene (Dantrium)
Side Effects
i. hepatotoxicity - can be fatal
ii. muscle weakness
iii. drowsiness, diarrhea
dantrolene (Dantrium)
Nursing Implications
i. monitor LFTs (hepatotoxicity)
ii. assess muscle strength decline
iii. administer in the lowest dose in shortest duration
iv. avoid alcohol and CNS depressants
v. give with food