10 Canine Osteosarcoma

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Canine appendicular osteosarcoma is the most common primary bone tumor. It involves malignant osteo(clasts/blasts) and active, normal osteo(clasts/blasts).

They tend to affect larger to giant breed dogs, and have a _____ age distribution.
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Terms in this set (13)
Canine appendicular osteosarcoma is the most common primary bone tumor. It involves malignant osteo(clasts/blasts) and active, normal osteo(clasts/blasts).

They tend to affect larger to giant breed dogs, and have a _____ age distribution.
malignant osteoblasts
normal osteoclasts

bimodal age distribution
What are the most common OSA locations in a dog?
"Away from the elbow, towards the knee"
80% in long bones
*distal radius
proximal humerus*
distal femur
proximal tibia
Name two risks of biopsy in a potential OSA case
-increased lameness
-pathologic fracture
-non-diagnostic sample
-contamination of bx tract caution if you want to do limb-spare
What is better to dx OSA, biopsy or FNA?
FNA
90% of OSA cases have microscopic mets at the time of diagnosis. Where do OSA's met most commonly? What's the best way to detect these mets?
lungs (CT most sensitive)
bone (nuclear scintigraphy = bone scan)
lymph nodes
You've just diagnosed a dog with OSA. The owner wants to know the treatment options.
Palliative:
-_________
-_________
-_________

Curative intent:
-_________
-_________
-_________

Chemotherapy (adjunct)
-_________
Palliative:
-pain meds
-bisphosphonates (causes osteoclast death)
-palliative radiation

Curative intent:
-amputation
-surgical limb spare
-sterotactic radiosurgery (SRS)

Chemotherapy (adjunct):
-Carboplatin for 4-6 doses
What is the most common site for an OSA tumor that could be treated with a limb spare?
distal radius, <50% of bone lenght affected

note: they must have chemo with limb spare
Age is a controversial prognostic factor when it comes to OSA. Dr. LeJeune believes that (younger/older) animals tend to have more aggressive disease and do worse
younger
Which OSA location carries a worse prognosis?
distal radius
proximal humerus
distal femur
proximal tibia
proximal humerus
Which blood chemistry marker is a negative prognostic indicator if it is elevated?
ALP
A dog generally has ~2 mos survival if there is evidence of __ or __ metastasis.Lymph node metastasis gross metastasisOSA has locally destructive, painful bone lesions with a (low/high) potential for systemic metastasis.highOSA amputation alone gives a MST of... -1 mo -4 mos -6 mos -12 mos4 mos