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5 Written questions

5 Matching questions

  1. target modification
  2. monobactams
  3. toxic dose
  4. gentamicin
  5. bacitracin
  1. a concentration of a drug that causes harm to the host
  2. b active against aerobic, gram negative rods; narrow spectrum; low toxicity; used for noscomial diseases and bacterial meningitis
  3. c used against gram negative infections of the urinary tract
  4. d polypeptide antibiotic; interferes with transport of cell wall precursors through the cell membrane; toxic internally so used topically
  5. e bacteria evolve changes in drug targets like ribosomes or enzymes involved in replication

5 Multiple choice questions

  1. history of chemotherapy originated with this man; came up with concept of selective toxicity
  2. broad spectrum; used for tb; can cause auditory damage
  3. effective against gram positive bacteria but is a last resort because it produces allergic reactions and is highly toxic to mitochondria
  4. drugs derived from the metabolism of living microorganisms; work to kill or inhibit living organisms
  5. increase membrane permeability of gram negative bacteria; topical use

5 True/False questions

  1. efficacyability to produce the necessary or desired result

          

  2. Penicillininhibits the peptide crosslinking of carbohydrates between peptidoglycan layers during wall formation

          

  3. selective toxicitysays that antimicrobial agent should harm the the infectious agent but not the host

          

  4. penicillinaseinactivates penicillin by opening the beta lactam ring

          

  5. chemotherapeutic indexused to treat infections, diseases, and other disorders such as cancer