Emotional lability, slurred speech, ataxia, coma, blackouts. GGT is a sensitive indicator of alcohol USE. AST 2x ALT
Mild alcohol withdrawal
Anxiety, tremor, seizures, insomnia
Severe alcohol withdrawal
DTs- Life threatening alcohol withdrawal syndrome that PEAKS 2-5 days after last drink. Autonomic system hyperactivity (tachycardia, tremors, anxiety, seizures) --> psychotic symptoms (hallucinations, delusions) --> confusion. Treat with benzos
CNS depression, nausea, vomiting, constipation, pinpoint pupils, seizures (OD life threatening). Treat: naloxone, naltrexone
Deficiency of B1(thiamine). Confusion, opthalmoplegia, ataxia (Korsakoff's encephalopathy). Can progress to irrversible memory loss, confabulation, personality change (Korsakoff's psychosis). Associated with PERIVENTRICULAR hemorrhage and necrosis of mammillary bodies. Treat: IV B1
Longitudinal lacerations at the GE junction caused by excessive vomiting. Presents with hematemesis. Associated with PAIN unlike esophageal varices.