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Terms in this set (3)
Heberden's vs Bouchard's Nodes
In OA, there is an increase in rate of synthesis and in secretion of matrix-degrading enzymes. Of the MMPs and TIMPs, which is increased and which is decreased?
MMPs (matrix metalloproteinases) - increased
TIMPs (tissue inhibitors of metalloproteinases) - decreased
Which 2 cytokines are involved in stimulating chondrocytes to produce proteinases and suppress cartilage matrix synthesis?
What other 2 molecules are involved in this?
IL-1 and TNF-alpha
NO and PG (prostaglandins)
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