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RESPIRATORY -

Terms in this set (4)

Briefly explain how lungs develop
Human lungs develop from frontal to distal with epithelial progenitor cells lining the airways.
With the interaction with mesenchymal tissue (secreting certain factors inc. Fgf10), the epithelial progenitor cells proliferate and move further away from the Fgf10. They then start to differentiate and mature.
Mesenchymal cells then differentiate into the airway smooth muscle
Stem cells in the lungs based on the region where theyre expressed
PROXIMAL
submucosal basal cell - within the submucosal gland
basal cells - within the pseudostratified epithelium

DISTAL
variant club cells
bronchialveolar stem cells
alveolar precursor cells
Challenges in using stem cells for lung therapies
Complexity of the tissue
Diversity of the disease
Complexity of the tissue
There are 40-60 different cells in the lungs! meaning you probably cant use a single cell type to fix the problem
Lungs have more than 1 stem cell progenitors
The architecture and topology of the lung is highly complex
All these makes it really difficult to manipulate the microenvironment and not to mention, the paucity of cell surface markers to isolate and enrich each progenitor cells

Diversity of the disease
- changes in the microenvironment, epithelium and mesenchyme
Potential stem cell therapies for lung disease
using iPs
to re-cellurise naked lung tissue (all cellular components have been taken leaving behind only the ECM and intact 3D structure)

to generate mesenchymoangioblast (MCA) precursor and differentiate them into MSC
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