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zPrimary Billiary Cholangitis
Terms in this set (7)
Which bile ducts does PBC affect?
Small intralobular bile ducts
Which antibody is most specific for PBC?
AMA (98% specific)
ANA also commonly positive
tends to be raised in PBC?
Who gets PBC?
Middle aged women
95% women, most often 30-65 years old
Which diseases are classically associated with PBC?
- Sjogren's (affects 65-80% of people with PBC)
- Thyroid disease (10-15%)
- Limited cutaneous scleroderma (5-15%)
- Classic rheumatoid arthritis (5-10%)
Management of PBC?
Supportive management for itch: antihistamines, cholestyramine
If decompensated cirrhosis, the only definitive management is liver transplant
What screening should you do in a patient with PBC?
TSH - annual
DEXA - every 6 months
Vitamin D (vitamin A and K as well if bili >20) - annual
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