IV Vitamins

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Vitamin B1
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Terms in this set (111)
Vitamin B1
Thiamine hydrochloride, Thiamin
Vitamin B1
Indications:
-tx of deficiency where you need rapid restoration
-patients who are deficient and cant take orally d/t anorexia, nausea, vomiting, malabsorption
-alcoholic wenicke's encephalopathy and korsakoff
Vitamin B1
Other indications:
-anemia, megaloblastic anemia
-MS, MG
-sciatica, sensory neuropathy
-depression & anxiety
-alcoholism
Vitamin B1
Pharm:
Required for oxidative decarboxylation of
pyruvate to acetyl co-A
Required for decarboxylation of alpha-keto acids and metabolism of methionine, threonine, leucine, isoleucine and valine
Also works at nerve cell membrane to allow ions to cross membrane
Necessary for metabolism of fats, protein and CHO, especially CHO metabolism in the brain
Vitamin B1
Deficiency:
Neuro: confusion, anorexia, ataxia, polyneuritis
Musc/Skel: weakness, tenderness of calf muscles,
muscle wasting
Cardiac: tachycardia, palpitations, edema
GI: constipation, indigestion
Other: Beriberi, Wernicke-Korsakoff syndrome
Often deficient in geriatric population, also excessive use of alcohol or refined CHO increases requirements
Given IM to alcoholics (recall its a necessary cofactor in the metabolism of alcohol)
Vitamin B1
Dose:
10mg-400mg delivered by rapid drip or push (30-60min) have been studied in clinical trials
-can be administed daily
-often oral is adminstered alongside parenteral routes

Pregnancy: 5-10mg daily
Vitamin B1
Ci
-sensitivity to it

AE
A feeling of warmth
pruritus, urticaria, weakness, sweating, nausea, restlessness
hypersensitivity or life-threatening anaphylactic reaction,
especially after repeated injections
Testing for hypersensitivity only recommended in patients with history of multiple drug reactions
test with (1/100 dose) 0.1 mg intradermal
Collapse and death have been reported
Vitamin B1
Supplied 10mg/ml

Warning
-non compounded product may contain aluminum
Standard B complex formula
Thiamine HCl 100 mg/mL
Riboflavin 5' Phosphate 2 mg
Pyridoxine HCl 2 mg
Dexapanthenol 2 mg
Niacinamide 100 mg
Vitamin B1
Administration Notes:
-incompatible with Cu
-degrades rapidly at neutral pH, must be kept in fridge and away from light
-destabilizes folic acid in IV mixtures
Vitamin B2
Riboflavin, Riboflavin 5 Phosphate
Vitamin B2
Indications:
-deficiency states

Other indications:
-acne
-pre cataracts and cataracts
-depression
Vitamin B2
Pharm
-Involved in production of FAD and FMD
-necessary for activation of B6
-Aids in beta-oxidation in fat metabolism
-Needed for production of corticosteroids, erythropoiesis, gluconeogenesis, thyroid regulation
- yellow and will make urine and breast milk yellow
-poorly absorbed > 30 mg orally
Vitamin B2
Deficiency
-occurs in conjunction with other B vitamin deficiencies
-cheilosis, glossitis are classic sx
-dry skin dry eyes
Vitamin B2
Dose
1-10mg as frequent as daily

CI
-hypersensitivity