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Terms in this set (28)
glyceraldehyde 3-P to 1,3-bisphosphoglycerate
oxidation with one NADH made as a prerequisite for ATP production in the next step
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reversible step, endergonic but close to zero
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the aldehyde is oxidized to a carboxylic acid with a phosphate
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glyceraldehyde-3-P dehydrogenase
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because when the phosphate group is removed the product of the removal (3-phosphoglycerate) is extremely stable due to resonance stabilization and so it is extremely favorable to convert to this product in the next step
oxidation with one NADH made as a prerequisite for ATP production in the next step
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reversible step, endergonic but close to zero
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the aldehyde is oxidized to a carboxylic acid with a phosphate
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glyceraldehyde-3-P dehydrogenase
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because when the phosphate group is removed the product of the removal (3-phosphoglycerate) is extremely stable due to resonance stabilization and so it is extremely favorable to convert to this product in the next step
both reactions are coupled to (1,3-bisphosphoglycerate -> 3-phosphoglycerate), 1,3-bisphosphoglycerate is the intermediate of the reactions so when all are coupled, the overall energy is exergonic and therefore favorable
to keep the endergonic energy low of the two first steps, the product concentrations are kept low to keep them bellow the exergonic value of the last step
to keep the endergonic energy low of the two first steps, the product concentrations are kept low to keep them bellow the exergonic value of the last step
when 1,3-bisphosphoglycerate is consumed in step 7, it keeps its concentration low, therefore, the q ratio is kept small which means ΔG will be very negative
this is important because we know multiple reasons why reactions 6 and 7 are coupled, why 1,3-bisphosphoglycerate is the intermediate between glyceraldehyde-3-P and 3-phosphoglycerate. We have mentioned enzyme channelling, coupling of rxns 6 and 7, how concentration levels impact, and how coupling of substrate-level phosphorylation of ATP to step 7 also allows this step to be very exergonic.
Q is another way to explain how reactions 6 and 7 are coupled through the common intermediate
this is important because we know multiple reasons why reactions 6 and 7 are coupled, why 1,3-bisphosphoglycerate is the intermediate between glyceraldehyde-3-P and 3-phosphoglycerate. We have mentioned enzyme channelling, coupling of rxns 6 and 7, how concentration levels impact, and how coupling of substrate-level phosphorylation of ATP to step 7 also allows this step to be very exergonic.
Q is another way to explain how reactions 6 and 7 are coupled through the common intermediate