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Question

______ inhibitor binds to a site on the enzyme that is not the active site.

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A noncompetitive inhibitor binds to an allosteric site (that differs from the active site) and can combine with either the free enzyme or the enzyme-substrate complex. This binding alters the enzyme’s 3D conformation, resulting in one of two outcomes: the enzyme-substrate not forming normally or it does not yield products as usual. Both of these result in decreased enzyme efficacy.

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