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Question

All cells contain an enzyme called peptidyl-tRNA hydrolase, and cells that are deficient in the enzyme grow very slowly. What is the probable function of the enzyme and why is it necessary?

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It releases tRNA from peptidyl–tRNA by cleaving the ester bond between the peptide and tRNA (Das et al)\textit{(Das et al)}. It hydrolyzes the ester bond before normal translation termination takes place. A premature polypeptide is non-functional as it is truncated. Peptidyl–tRNA hydrolase is necessary for recycling the amino acids and the tRNA.

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