T.B. is a 65 -year-old retiree who is admitted to your unit from the emergency department (ED). On arrival, you note that he is trembling and nearly doubled over with severe abdominal pain. T.B. indicates that he has severe pain in the right upper quadrant (RUQ) of his abdomen that radiates through to his mid back as a deep, sharp, boring pain. He is more comfortable walking or sitting bent forward rather than lying flat in bed. He admits to having had several similar bouts of abdominal pain in the last month, but "none as bad as this." He feels nauseated but has not vomited, although he did vomit a week ago with a similar episode. T.B. experienced an acute onset of pain after eating fried fish and chips at a fast-food restaurant earlier today. He is not happy to be in the hospital and is grumpy that his daughter insisted on taking him to the ED for evaluation.
After orienting him to the room, you perform your physical assessment. The findings are as follows: He is awake, alert, and oriented ×3, and he moves all extremities well. He is restless, constantly shifting his position, and complains of fatigue. Breath sounds are clear to auscultation. Heart sounds are clear with no murmur or rub noted and with a regular rhythm. His abdomen is flat, slightly rigid, and very tender to palpation throughout, especially in the RUQ; bowel sounds are present. He reports having light-colored stools for 1 week. The patient voids dark amber urine but denies dysuria. Skin and sclera are jaundiced. Admission vital signs are blood pressure 164/100, pulse of 132, respiration of 26, the temperature of 100∘F (37.8 ∘C),Spo2 96% on 2 L of oxygen by nasal cannula.
T.B.'s abdominal ultrasound demonstrates several retained stones in the common bile duct and a stone filled gallbladder. T.B. is admitted to your floor, placed on nothing by mouth (NPO) status, and scheduled to undergo endoscopic retrograde cholangiopancreatography (ERCP) that afternoon. T.B.'s other lab results are posted, and you review them.
Preoperative Laboratory Test Results:
WBC Hgb Hct Platelets ALT AST ALP Total bilirubin PT/INR Amylase Lipase Urinalysis 11,900/mm3(11.9×109/L)14.3 g/dL(143 g/L)43%250,000/mm3(250×109/L)200units/L260units/L450units/L4.8mg/dL(82mcmol/L)11.5sec/1.050 units /L23 units /L Negative
T.B. undergoes the ERCP, and stones and bile are released; however, imaging reveals that a stone is still retained within the cystic duct and multiple stones remain within the gallbladder itself. Surgical consultation is obtained, and laparoscopic cholecystectomy ("lap choley") is planned.
T.B. undergoes a successful laparoscopic cholecystectomy the next morning. An intraoperative cholangiogram shows that the ducts are finally cleared of stones at the conclusion of the surgery. When he returns to the nursing unit, his stomach is soft but quite distended. His wife asks you whether anything is wrong. As you review the orders, you note that Primaxin contains cilastatin. What is the purpose of cilastatin?
a. It enhances the action of the imipenem.
b. It reduces the chance of an allergic reaction.
c. It promotes the renal secretion of the imipenem.
d. It causes the bacterial cell wall to become unstable.