Case history 1. A male researcher wanting to determine the pathogenesis of a certain fungus that often attacks women did the following experiment on himself. He taped a piece of gauze heavily inoculated with the fungus to the inside of his thigh and left it there for several days, periodically moistening it with sterile saline. After a time, he experienced a severe skin reaction that resembled a burn and the skin peeled off What does this experiment tell you about the factors in pathogenesis related to portal of entry and gender?

Describe the difficulties in diagnosing endemic fungal infections that are acquired by travelers or nonnatives to endemic areas.

Histoplasmosis has the greatest endemic occurrence in which region?
a. midwestern United States
b. southwestern United States
c. Central and South America
d. North Africa

What features of the lungs make them a favorable site for fungal infections?

Example(s) of fungal infection(s) that is/are communicable is/are
a. dermatomycosis $\hspace{1cm}$c. sporotrichosis
b. candidiasis $\hspace{1.65cm}$d. both a and b

Suggest a reason that adult males have more cases of histoplasmosis.

Why would infections from soil and animal species be more virulent than ones from fungi adapted to humans?

Explain why some dermatophytes are considered good parasites.

Describe three forms of fungal toxinoses and the agents involved in them.

True pathogenic fungi
a. are transmissible from person to person
b. cause primary pulmonary infections
c. are endemic to specifi c geographic areas
d. both b and c

What is necessary in treatment?

What is the diffi culty in ridding the epidermal tissues of certain dermatophytes?

If you were tasked with preventing an outbreak similar to the one seen in the Case Study, what recommendations would you make to workers preparing to open a similar camp the following year?

Primary pathogenic fungi differ from opportunistic fungi in being
a. more virulent $\hspace{1cm}$c. more prevalent
b. less virulent $\hspace{1.25cm}$d. more transmissible