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Question

How did Watson and Crick make a useful inference from Franklin's X-ray studies of DNA?

Solution

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Rosalind Franklin made an X-ray image of the DNA molecule, that has revealed the following:

  1. The nitrogenous bases are near the center of the DNA molecule
  2. DNA molecule is composed out of two strands
  3. DNA molecule has the shape of a helix Watson and Crick made the first model of the DNA molecule based on that very picture. They concluded that the strands are antiparallel and that they are composed of nucleotides. Nucleotides of one strand are interconnected with covalent bonds, while two strands are connected with weak, hydrogen bonds. According to the Chargaff's rule, adenine always binds with thymine of the other strand, while guanine binds with cytosine that is a part of the antiparallel strand.

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