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DNA molecules consist of chemically linked sequences of the bases adenine, guanine, cytosine, and thymine, denoted A, G, C, and T. A sequence of three bases is called a codon. A base may appear more than once in a codon. a. How many different codons are there? b. The bases A and G are purines, while C and T are pyrimidines. How many codons are there whose first and third bases are purines and whose second base is a pyrimidine? c. How many codons consist of three different bases?

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(a) Fundamental counting principle\textbf{Fundamental counting principle}: If the first event could occur in mm ways and the second event could occur in nn ways, then the number of ways that the two events could occur in sequence is mnm\cdot n.

A codon is a sequence of three bases, while there are four bases (A, G, C, T).

First base: 4 ways

Second base: 4 ways

Third base: 4 ways

Use the fundamental counting principle:

444=43=644\cdot 4\cdot 4=4^3=64

Thus there are 64 different codons.

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