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Question
Draw structures that show the similarity between the decarboxylation of the pyruvate–TPP intermediate and the decarboxylation of a β-keto acid.
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Answered 2 years ago
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1 of 2Pyruvate-TPP intermediate and -keto acid undergo decarboxylation in a similar manner. The tetrahedral TPP intermediate undergoes decarboxylation because the electrons left behind when is removed are delocalized onto the positively charged nitrogen. Similarly, decarboxylation of -keto acid also takes place to give an enol intermediate.
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