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Question

How does the tertiary structure of a protein determine protein's solubility?

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Answered 8 months ago
Answered 8 months ago

The tertiary structure of a protein determines its solubility through the formation of hydrophobic and hydrophilic interactions. Hydrophobic interactions between non-polar side chains cause the formation of a compact, insoluble structure, while hydrophilic interactions between polar or charged side chains allow the protein to dissolve in aqueous environments. The balance between hydrophobic and hydrophilic interactions determines the overall solubility of the protein.

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