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Genes that cause Prader-Willi syndrome and Angelman syndrome are closely linked along chromosome 15 . Although people with these syndromes do not usually reproduce, let's suppose that a couple produces two children with Angelman syndrome. The oldest child (named Pat) grows up and has two children with PraderWilli syndrome. The second child (named Robin) grows up and has one child with Angelman syndrome.
A. Are Pat and Robin's parents both normal or does one of them have Angelman or Prader-Willi syndrome? If one of them has a disorder, explain why it is the mother or the father.
B. What are the sexes of Pat and Robin? Explain.
Person with cystic fibrosis inherited two mutated alleles, one from each parent, which causes a removal of three bases from the DNA molecule. Unlike cystic fibrosis, in a person with Down syndrome there is a third copy of 21 chromosome, so instead of heaving two 21 chromosomes, person has three chromosomes or trisomy of 21 chromosome.
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